KIR-HLA intercourse in HIV disease

被引：110

作者：

Carrington, Mary ^{[1
]}

Martin, Maureen P. ^{[1
]}

van Bergen, Jeroen ^{[2
]}

机构：

[1] NCI, SAIC Frederick Inc, Expt Immunol Lab, Canc & Inflammat Program, Frederick, MD 21702 USA

[2] Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, Sect Immunochem, NL-2333 ZA Leiden, Netherlands

来源：

TRENDS IN MICROBIOLOGY | 2008年 / 16卷 / 12期

关键词：

D O I：

10.1016/j.tim.2008.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human leukocyte antigen (HLA) class I loci are essential to an effective immune response against a wide variety of pathogenic microorganisms, and they represent the prototypes for genetic polymorphism that are sustained through balancing selection. The functional significance of HLA class I variation is better exemplified by studies involving HIV type 1 (HIV-1) than any other infectious organism. HLA class I molecules are essential to the acquired immune response, but they are also important in innate immunity as ligands for the killer cell immunoglobulin-like receptors (KIR), which modulate natural killer cell activity. Here we concentrate on the interaction between the HLA-B and KIR3DL1/KIR3DS1 genes, describe the effects of these loci on HIV disease, and discuss questions that remain unresolved.

引用

页码：620 / 627

页数：8

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