Anticlastogenic effect of vitamin C on cisplatin in vivo

被引：17

作者：

Antunes, LMG ^{[1
]}

Darin, JDC ^{[1
]}

Bianchi, MDP ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14041903 Ribeirao Preto, SP, Brazil

来源：

GENETICS AND MOLECULAR BIOLOGY | 1999年 / 22卷 / 03期

关键词：

D O I：

10.1590/S1415-47571999000300022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of vitamin C (VC) to protect against the clastogenic action of the chemotherapeutic agent cisplatin (DDP, cis-diamminedichloroplatinun II) in rat bone marrow cells was evaluated. DDP was administered to Wistar rats either alone or after treatment with VC. The rats were treated with VC (50, 100 or 200 mg/kg body weight) by gavage 10 min before the administration of DDP (5 mg/kg body weight, ip) and then sacrificed 24 h after treatment. VC significantly reduced (by about 70%) the clastogenicity of DDP in rat bone marrow cells. The antioxidant action of VC presumably modulates the clastogenic action of DDP.

引用

页码：415 / 417

页数：3

共 27 条

[1] CLASTOGENIC EFFECTS OF CIS-DIAMMINEDICHLOROPLATINUM .1. INDUCTION OF CHROMOSOMAL-ABERRATIONS IN SOMATIC AND GERMINAL CELLS OF MICE [J].