Where is the vitamin D receptor?

被引：638

作者：

Wang, Yongji ^{[1
]}

Zhu, Jinge ^{[1
]}

DeLuca, Hector F. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2012年 / 523卷 / 01期

关键词：

Vitamin D receptor; Gene expression; Transcriptional factor; Calcium; 1,25-DIHYDROXYVITAMIN D-3 RECEPTOR; 1,25 (OH)2 VITAMIN-D3; MEDIATE TRANSCRIPTIONAL AUTOREGULATION; HAMSTER PHODOPUS-SUNGORUS; D-RESPONSE ELEMENT; MALE SEX-ORGANS; PARATHYROID-HORMONE; GENE-EXPRESSION; TARGET-CELLS; IN-VIVO;

D O I：

10.1016/j.abb.2012.04.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The vitamin D receptor (VDR) is a member of the nuclear receptor superfamily and plays a central role in the biological actions of vitamin D. VDR regulates the expression of numerous genes involved in calcium/phosphate homeostasis, cellular proliferation and differentiation, and immune response, largely in a ligand-dependent manner. To understand the global function of the vitamin D system in physiopathological processes, great effort has been devoted to the detection of VDR in various tissues and cells, many of which have been identified as vitamin D targets. This review focuses on the tissue- and cell type-specific distribution of VDR throughout the body. (C) 2012 Elsevier Inc. All rights reserved.

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页码：123 / 133

页数：11

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