Alternative synthesis of the chiral atypical β-adrenergic phenylethanolaminotetraline agonist SR58611A using enantioselective hydrogenation

被引：53

作者：

Devocelle, M ^{[1
]}

Mortreux, A ^{[1
]}

Agbossou, F ^{[1
]}

Dormoy, JR ^{[1
]}

机构：

[1] ENSCL, Catalyse Lab, CNRS, F-59652 Villeneuve Dascq, France

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(99)00807-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed an alternative synthesis of the atypical P-adrenergic phenylethanolaminotetraline agonist SR58611A. Two key intermediates have been synthesised involving enantioselective hydrogenation of an aminoketone and an enamide providing the corresponding amino alcohol and amide in >96 and >98 % ee respectively. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4551 / 4554

页数：4

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