HLA-A and -B alleles in cornea donors as risk factors for graft rejection

被引:10
作者
Creemers, PC
Kahn, D
Hill, JC
机构
[1] Univ Cape Town, Dept Immunol, ZA-7925 Cape Town, South Africa
[2] Univ Cape Town, Dept Surg, ZA-7925 Cape Town, South Africa
[3] Univ Cape Town, Dept Ophthalmol, ZA-7925 Cape Town, South Africa
[4] Groote Schuur Hosp, ZA-7925 Cape Town, South Africa
关键词
D O I
10.1016/S0966-3274(99)80014-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We determined the human leucocyte antigen (HLA)-A, -B and -DR allele frequencies in recipients and donors of 115 cornea transplants, for recipients who developed graft rejection and those who did not. No difference in HLA allele frequencies of the recipients was found. The frequencies of the HLA-A26, -B35 and -B44 alleles in cornea donors were increased in recipients who developed graft failure. The detrimental effect on corneal graft survival of these alleles was significant (p < 0.001). No such effect was observed in renal transplantation. Corneal graft survival was similar when one or two A26, B35 or B44 alleles were present on the donor cornea. The negative effect was similar in magnitude to the previously reported negative effect of an HLA-B locus match between donor and recipient, When both a B-locus match and an A26, B35 or B44 allele were present, the negative effect on graft survival was twice as strong, indicating that different immune mechanisms are responsible for these phenomena.
引用
收藏
页码:15 / 18
页数:4
相关论文
共 17 条
[1]  
BRADLEY BA, 1995, TRANSPLANT P, V27, P1392
[2]  
DAMARO J, 1992, HLA 1991 P 11 INT HI, V2, P478
[3]  
DUTOIT ED, 1988, TISSUE ANTIGENS, V31, P109
[4]   A COMPARISON OF CORNEAL, PANCREAS, AND SKIN CRAFTS IN MICE - A STUDY OF THE DETERMINANTS OF TISSUE IMMUNOGENICITY [J].
GUYMER, RH ;
MANDEL, TE .
TRANSPLANTATION, 1994, 57 (08) :1251-1262
[5]  
Hill JC, 1997, TRANSPL INT, V10, P145
[6]  
Hill JC, 1996, GER J OPHTHALMOL, V5, P36
[7]  
ITESCU S, 1992, J ACQ IMMUN DEF SYND, V5, P37
[8]   ASSEMBLY AND INTRACELLULAR-TRANSPORT OF MHC CLASS-I MOLECULES [J].
JACKSON, MR ;
PETERSON, PA .
ANNUAL REVIEW OF CELL BIOLOGY, 1993, 9 :207-235
[9]  
MANEZ R, 1995, TRANSPLANTATION, V59, P640
[10]   THE INFLUENCE OF HLA MATCHING ON CYTOMEGALOVIRUS HEPATITIS AND CHRONIC REJECTION AFTER LIVER-TRANSPLANTATION [J].
MANEZ, R ;
WHITE, LT ;
LINDEN, P ;
KUSNE, S ;
MARTIN, M ;
KRAMER, D ;
DEMETRIS, AJ ;
VANTHIEL, DH ;
STARZL, TE ;
DUQUESNOY, RJ .
TRANSPLANTATION, 1993, 55 (05) :1067-1071