Protective effect of epigallocatechin-3-gallate on ischemia/reperfusion-induced injuries in the heart: STAT1 silencing flavonoid

被引：16

作者：

Darra, Elena ^{[1
]}

Shoji, Kazuo ^{[1
]}

Mariotto, Sofia ^{[1
]}

Suzuki, Hisanori ^{[1
]}

机构：

[1] Univ Verona, Dept Morphol & Biomed Sci, Biochem Sect, I-37100 Verona, Italy

来源：

GENES AND NUTRITION | 2007年 / 2卷 / 03期

关键词：

D O I：

10.1007/s12263-007-0060-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

The beneficial effect of naturally occurring flavonoids in health is believed to be due to their strong antioxidant activity. However, recent laboratory evidence indicates the involvement of a more specific action. Here, we present evidence that, among a number of catechins present in green tea extract, only epigallocatechin-3-gallate (EGCG) exerts a strong inhibitory action on interferon-celicited activation of signal transducer and activator of transcription 1 (STAT1). Protective action of EGCG in ischemia/reperfusion injury in the heart and the molecular mechanism of action, which has nothing to do with its antioxidant capacity are described.

引用

页码：307 / 310

页数：4

共 40 条

[1]

A road map for those who don't know JAK-STAT [J].