Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure

被引：215

作者：

Gora, Michalina J. ^{[1
,2
]}

Sauk, Jenny S. ^{[2
,3
]}

Carruth, Robert W. ^{[1
,2
]}

Gallagher, Kevin A. ^{[1
,2
]}

Suter, Melissa J. ^{[4
]}

Nishioka, Norman S. ^{[1
,2
,3
]}

Kava, Lauren E. ^{[1
,2
]}

Rosenberg, Mireille ^{[1
,2
]}

Bouma, Brett E. ^{[1
,2
]}

Tearney, Guillermo J. ^{[1
,2
,5
,6
]}

机构：

[1] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Dept Gastroenterol, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Dept Pulmonol, Boston, MA 02114 USA

[5] Harvard MIT Hlth Sci & Technol, Cambridge, MA USA

[6] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

来源：

NATURE MEDICINE | 2013年 / 19卷 / 02期

基金：

美国国家卫生研究院;

关键词：

OPTICAL COHERENCE TOMOGRAPHY; BARRETTS-ESOPHAGUS; INTESTINAL METAPLASIA; FEASIBILITY; ENDOSCOPY; DIAGNOSIS;

D O I：

10.1038/nm.3052

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here we introduce tethered capsule endomicroscopy, which involves swallowing an optomechanically engineered pill that captures cross-sectional microscopic images of the gut wall at 30 mu m (lateral) x 7 mu m (axial) resolution as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural images of the upper gastrointestinal tract in a simple and painless procedure, opening up new opportunities for screening for internal diseases.

引用

页码：238 / 240

页数：3

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