West Nile virus infection and immunity

被引：309

作者：

Suthar, Mehul S. ^{[1
]}

Diamond, Michael S. ^{[2
,3
,4
]}

Gale, Michael, Jr. ^{[1
,5
]}

机构：

[1] Univ Washington, Sch Med, Dept Immunol, Seattle, WA 98195 USA

[2] Washington Univ, Dept Med, St Louis, MO 63110 USA

[3] Washington Univ, Dept Mol Microbiol, St Louis, MO 63110 USA

[4] Washington Univ, Dept Pathol & Immunol, St Louis, MO 63110 USA

[5] Univ Washington, Dept Microbiol, Sch Med, Seattle, WA 98195 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2013年 / 11卷 / 02期

基金：

美国国家卫生研究院;

关键词：

CD8(+) T-CELLS; TOLL-LIKE RECEPTOR-3; NONSTRUCTURAL PROTEIN NS1; TUMOR-NECROSIS-FACTOR; DOUBLE-STRANDED-RNA; RIG-I; ALPHA/BETA-INTERFERON; COMPLEMENT ACTIVATION; INTRAVENOUS IMMUNOGLOBULIN; NEUTRALIZING ANTIBODY;

D O I：

10.1038/nrmicro2950

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

West Nile virus (WNV) is an emerging neurotropic flavivirus that is transmitted to humans through the bite of an infected mosquito. WNV has disseminated broadly in the Western hemisphere and now poses a significant public health risk. The continuing spread of WNV, combined with the lack of specific therapeutics or vaccines to combat or prevent infection, imparts a pressing need to identify the viral and host processes that control the outcome of and immunity to WNV infection. Here, we provide an overview of recent research that has revealed the virus host interface controlling WNV infection and immunity.

引用

页码：115 / 128

页数：14

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