Clinical application of targeted and genome-wide technologies: can we predict treatment responses in chronic lymphocytic leukemia?

被引：9

作者：

Alsolami, Reem ^{[1
,2
]}

Knight, Samantha J. L. ^{[1
,3
]}

Schuh, Anna ^{[1
]}

机构：

[1] Univ Oxford, Res Biomed Res Ctr, Oxford Natl Inst Hlth, Oxford, England

[2] King Abdulaziz Univ, Fac Appl Med Sci, Jeddah 21413, Saudi Arabia

[3] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England

来源：

PERSONALIZED MEDICINE | 2013年 / 10卷 / 04期

基金：

英国惠康基金;

关键词：

chronic lymphocytic leukemia; genome-wide technologies; massively parallel sequencing; next-generation technology; predictive biomarker; prognostic biomarker; SNP microarray; LRF CLL4 TRIAL; ACUTE MYELOID-LEUKEMIA; DENSITY SNP ARRAYS; TERM-FOLLOW-UP; CLONAL EVOLUTION; COPY-NUMBER; NOTCH1; MUTATIONS; SF3B1; TP53; MUTATION; B-CLL;

D O I：

10.2217/PME.13.33

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chronic lymphocytic leukemia (CLL) is low-grade lymphoma of mature B cells and it is considered to be the most common type of hematological malignancy in the western world. CLL is characterized by a chronically relapsing course and clinical and biological heterogeneity. Many patients do not require any treatment for years. Although important progress has been made in the treatment of CLL, none of the conventional treatment options are curative. Recurrent chromosomal abnormalities have been identified and are associated with prognosis and pathogenesis of the disease. More recently, unbiased genome-wide technologies have identified multiple additional recurrent aberrations. The precise predictive value of these has not been established, but it is likely that the genetic heterogeneity observed at least partly reflects the clinical variability. The present article reviews our current knowledge of predictive markers in CLL using whole-genome technologies.

引用

页码：361 / 376

页数：16

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