Serial changes in cardiovascular and renal function of rabbits ingesting a high-fat, high-calorie diet

被引：23

作者：

Antic, V ^{[1
]}

Tempini, A ^{[1
]}

Montani, JP ^{[1
]}

机构：

[1] Univ Fribourg, Inst Physiol, CH-1700 Fribourg, Switzerland

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1999年 / 12卷 / 08期

关键词：

obesity; hypertension; rabbits; high-fat diet; telemetry;

D O I：

10.1016/S0895-7061(98)00231-3

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

To explore the mechanisms of obesity-induced hypertension we analyzed the sequential changes in cardiovascular and renal function in adult rabbits switched to high-fat diet (HFD) for 8 weeks. Animals were housed in metabolic cages for continuous 24-h recording of arterial pressure by telemetry and daily urine collection. High-fat diet induced a progressive increase in body weight (+47%) and a rapid rise in mean arterial pressure, heart rate, and glomerular filtration rate that stabilized, respectively, at 1.4%, 31% and 68% greater than control values. Time-course analysis of changes in blood pressure may reveal two components of obesity-induced hypertension, an early phase related to HFD itself and a later phase related to weight gain. (C) 1999 American Journal of Hypertension, Ltd.

引用

页码：826 / 829

页数：4

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