Late relapse of acute myeloid leukemia with mutated NPM1 after eight years: evidence of NPM1 mutation stability

被引:28
作者
Meloni, Giovanna [2 ]
Mancini, Marco [2 ]
Gianfelici, Valentina [2 ]
Martelli, Maria Paola
Foa, Robin [2 ]
Falini, Brunangelo [1 ]
机构
[1] Univ Perugia, Inst Hematol, Sect Hematol & Immunol, IBit Fdn, I-06100 Perugia, Italy
[2] Univ Roma La Sapienza, Dipartimento Biotecnol Cellulari & Ematol, Div Hematol, Rome, Italy
来源
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2009年 / 94卷 / 02期
关键词
acute myeloid leukemia; nucleophosmin; NPM1; mutation; normal karyotype; ACUTE MYELOGENOUS LEUKEMIA; CYTOPLASMIC NUCLEOPHOSMIN; DISEASE; MODEL;
D O I
10.3324/haematol.2008.000059
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:298 / 300
页数:3
相关论文
共 12 条
[1]   Cytoplasmic nucleophosmin in myeloid sarcoma occurring 20 years after diagnosis of acute myeloid leukaemia [J].
Bolli, N ;
Galimberti, S ;
Martelli, MP ;
Tabarrini, A ;
Roti, G ;
Mecucci, C ;
Martelli, MF ;
Petrini, M ;
Falini, B .
LANCET ONCOLOGY, 2006, 7 (04) :350-352
[2]   Nucleophosmin mutations in De novo acute myeloid leukemia:: The age-dependent incidences and the stability during disease [J].
Chou, WC ;
Tang, JL ;
Lin, LI ;
Yao, M ;
Tsay, W ;
Chen, CY ;
Wu, SJ ;
Huang, CF ;
Chiou, RJ ;
Tseng, MH ;
Lin, DT ;
Lin, KH ;
Chen, YC ;
Tien, HF .
CANCER RESEARCH, 2006, 66 (06) :3310-3316
[3]   Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. [J].
Falini, B ;
Mecucci, C ;
Tiacci, E ;
Alcalay, M ;
Rosati, R ;
Pasqualucci, L ;
La Starza, R ;
Diverio, D ;
Colombo, E ;
Santucci, A ;
Bigerna, B ;
Pacini, R ;
Pucciarini, A ;
Liso, A ;
Vignetti, M ;
Fazi, P ;
Meani, N ;
Pettirossi, V ;
Saglio, G ;
Mandelli, F ;
Lo-Coco, F ;
Pelicci, P ;
Martelli, MF .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (03) :254-266
[4]   Cytoplasmic mutated nucleophosmin is stable in primary leukemic cells and in a xenotransplant model of NPMc+ acute myeloid leukemia in SCID mice [J].
Falini, Brunangelo ;
Martelli, Maria Paola ;
Mecucci, Cristina ;
Liso, Arcangelo ;
Bolli, Niccolo ;
Bigerna, Barbara ;
Pucciarini, Alessandra ;
Pileri, Stefano ;
Meloni, Giovanna ;
Martelli, Massimo F. ;
Haferlach, Torsten ;
Schnittger, Susanne .
HAEMATOLOGICA, 2008, 93 (05) :775-779
[5]   Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML):: biologic and clinical features [J].
Falini, Brunangelo ;
Nicoletti, Ildo ;
Martelli, Massimo F. ;
Mecucci, Cristina .
BLOOD, 2007, 109 (03) :874-885
[6]   Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia [J].
Falini, Brunangelo ;
Martelli, Maria Paola ;
Bolli, Niccolo ;
Bonasso, Rossella ;
Ghia, Emanuela ;
Pallotta, Maria Teresa ;
Diverio, Daniela ;
Nicoletti, Ildo ;
Pacini, Roberta ;
Tabarrini, Alessia ;
Galletti, Barbara Verducci ;
Mannucci, Roberta ;
Roti, Giovanni ;
Rosati, Roberto ;
Specchia, Giorgina ;
Liso, Arcangelo ;
Tiacci, Enrico ;
Alcalay, Myriam ;
Luzi, Lucilla ;
Volorio, Sara ;
Bernard, Loris ;
Guarini, Anna ;
Amadori, Sergio ;
Mandelli, Franco ;
Pane, Fabrizio ;
Lo-Coco, Francesco ;
Saglio, Giuseppe ;
Pelicci, Pier-Giuseppe ;
Martelli, Massimo F. ;
Mecucci, Cristina .
BLOOD, 2006, 108 (06) :1999-2005
[7]   The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia [J].
Gale, Rosemary E. ;
Green, Claire ;
Allen, Christopher ;
Mead, Adam J. ;
Burnett, Alan K. ;
Hils, Robert K. ;
Linch, David C. .
BLOOD, 2008, 111 (05) :2776-2784
[8]   Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin [J].
Garzon, Ramiro ;
Garofalo, Michela ;
Martelli, Maria Paola ;
Briesewitz, Roger ;
Wang, Lisheng ;
Fernandez-Cymering, Cecilia ;
Volinia, Stefano ;
Liu, Chang-Gong ;
Schnittger, Susanne ;
Haferlach, Torsten ;
Liso, Arcangelo ;
Diverio, Daniela ;
Mancini, Marco ;
Meloni, Giovanna ;
Foa, Robin ;
Martelli, Massimo F. ;
Mecucci, Cristina ;
Croce, Carlo M. ;
Falini, Brunangelo .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (10) :3945-3950
[9]   A one-mutation mathematical model can explain the age incidence of acute myeloid leukemia with mutated nucleophosmin (NPM1) [J].
Liso, Arcangelo ;
Castiglione, Filippo ;
Cappuccio, Antonio ;
Stracci, Fabrizio ;
Schlenk, Richard F. ;
Amadori, Sergio ;
Thiede, Christian ;
Schnittger, Susanne ;
Valk, Peter J. M. ;
Doehner, Konstanze ;
Martelli, Massimo F. ;
Schaich, Markus ;
Krauter, Juergen ;
Ganser, Arnold ;
Martelli, Maria P. ;
Bolli, Niccolo ;
Loewenberg, Bob ;
Haferlach, Torsten ;
Ehninger, Gerhard ;
Mandelli, Franco ;
Doehner, Hartmut ;
Michor, Franziska ;
Falini, Brunangelo .
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 (08) :1219-1226
[10]   Characteristics and outcomes of acute myelogenous leukemia patients with very late relapse (>5 years) [J].
Medeiros, Bruno C. ;
Minden, Mark D. ;
Schuh, Andre C. ;
Schimmer, Aaron D. ;
Yee, Karen ;
Lipton, Jeff H. ;
Messner, Hans A. ;
Gupta, Vikas ;
Chun, Kathy ;
Xu, Wei ;
Das, Prabodh ;
Kamel-Reid, Suzanne ;
Brandwein, Joseph M. .
LEUKEMIA & LYMPHOMA, 2007, 48 (01) :65-71