Further Genetic Evidence for Three Psoriasis-Risk Genes: ADAM33, CDKAL1, and PTPN22

被引：61

作者：

Li, Yonghong ^{[1
]}

Liao, Wilson ^{[2
]}

Chang, Monica ^{[1
]}

Schrodi, Steven J. ^{[1
]}

Bui, Nam ^{[1
]}

Catanese, Joseph J. ^{[1
]}

Poon, Annie ^{[2
]}

Matsunami, Nori ^{[3
]}

Callis-Duffin, Kristina P. ^{[4
]}

Leppert, Mark F. ^{[3
,5
]}

Bowcock, Anne M. ^{[6
,7
,8
]}

Kwok, Pui-Yan ^{[2
]}

Krueger, Gerald G. ^{[3
]}

Begovich, Ann B. ^{[1
]}

机构：

[1] Celera, Discovery Res, Alameda, CA 94502 USA

[2] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA

[3] Univ Utah, Dept Human Genet, Salt Lake City, UT USA

[4] Univ Utah, Dept Dermatol, Salt Lake City, UT USA

[5] LineaGen Res Corp, Salt Lake City, UT USA

[6] Washington Univ, Sch Med, Dept Genet, Div Human Genet, St Louis, MO 63110 USA

[7] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA

[8] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2009年 / 129卷 / 03期

关键词：

GENOME-WIDE ASSOCIATION; TYROSINE-PHOSPHATASE; SUSCEPTIBILITY LOCI; POLYMORPHISMS; IL12B; IL23R; INTERLEUKIN-15; VARIANTS; VULGARIS; SEQUENCE;

D O I：

10.1038/jid.2008.297

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Predisposition to psoriasis is known to be affected by genetic variation in HLA-C, IL12B, and IL23R, and although other psoriasis-associated variants have been identified, incontrovertible statistical evidence for these markers has not yet been obtained. To help resolve this issue, we tested 15 single-nucleotide polymorphisms ( SNPs) from 7 putative psoriasis-risk genes in 1,448 psoriasis patients and 1,385 control subjects; 3 SNPs, rs597980 in ADAM33, rs6908425 in CDKAL1 and rs3789604 in PTPN22, were significant with the same risk allele as in prior reports (one-sided P < 0.05, false discovery rate < 0.15). These three markers were tested in a fourth sample set (599 cases and 299 controls); one marker, rs597980, replicated (one-sided P < 0.05) and the other two had odds ratios with the same directionality as in the original sample sets. Mantel-Haenszel meta-analyses of all available case-control data, including those published by other groups, showed that these three markers were highly significant (rs597980: P = 0.0057 (2,025 cases and 1,597 controls), rs6908425: P 1.57 x 10(-5) ( 3,206 cases and 4,529 controls), and rs3789604: P 3.45 x 10(-5) (2,823 cases and 4,066 controls)). These data increase the likelihood that ADAM33, CDKAL1, and PTPN22 are true psoriasis-risk genes.

引用

页码：629 / 634

页数：6

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