Potential effects of amoxycillin/clavulanic acid and ticarcillin/clavulanic acid on human granulocyte activity: A comparative study

被引：11

作者：

Cuffini, AM ^{[1
]}

Tullio, V ^{[1
]}

Paizis, G ^{[1
]}

Carlone, NA ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM, MILAN, ITALY

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1996年 / 38卷 / 06期

关键词：

D O I：

10.1093/jac/38.6.1013

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The efficacy of an antimicrobial agent in the therapy of infection depends upon the interaction of bacteria, antibiotic and phagocytes. The influence of both ticarcillin/clavulanic acid and amoxycillin/clavulanic acid on the phagocytic and bactericidal activity of human PMNs in vitro was investigated. The results show that clavulanic acid, with its beta-lactamase inhibitory properties, potentiated the efficacy of both ticarcillin and amoxycillin, resulting in a significantly increased susceptibility of a beta-lactamase producing strain of Klebsiella pneumoniae to phagocytic and microbicidal activities of human PMNs. Overall, amoxycillin/clavulanic acid showed greater enhancement of the killing of K. pneumoniae by human PMNs.

引用

页码：1013 / 1022

页数：10

共 21 条

[1] COMPARATIVE ACTIVITIES OF AMOXICILLIN, AMOXICILLIN CLAVULANIC ACID AND TETRACYCLINE AGAINST CHLAMYDIA-TRACHOMATIS IN CELL-CULTURE AND IN AN EXPERIMENTAL MOUSE PNEUMONITIS [J].