Early adoption modifies the effects of prenatal stress on dopamine and glutamate receptors in adult rat brain

被引:61
作者
Barros, VG
Berger, MA
Martijena, ID
Sarchi, MI
Pérez, AA
Molina, VA
Tarazi, FI
Antonelli, MC
机构
[1] Univ Buenos Aires, Fac Farm & Bioquim, CONICET, IQUIFIB, RA-1113 Buenos Aires, DF, Argentina
[2] Univ Cordoba, Fac Ciencias Quim, Dept Farmacol, RA-1113 Cordoba, Argentina
[3] Univ Buenos Aires, Fac Farm & Bioquim, Dept Fisicomatemat, RA-1113 Buenos Aires, DF, Argentina
[4] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Lab Biometria, RA-1113 Buenos Aires, DF, Argentina
[5] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
[6] Harvard Univ, Sch Med, Neurosci Program, Boston, MA 02115 USA
[7] Massachusetts Gen Hosp, McLean Div, Mailman Res Ctr, Belmont, MA USA
关键词
dopamine D-2 receptors; glutamate NMDA receptors; testis descent; prenatal stress; cross-fostering; quantitative autoradiography;
D O I
10.1002/jnr.20119
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Stressful stimuli during pregnancy induce complex effects that influence the development of offspring. These effects can be prevented by environmental manipulations during the early postnatal period. Repeated restraint during the last week of pregnancy was used as a model of prenatal stress, and adoption at birth was used to change the postnatal environment. No differences were found in various physical landmarks, except for testis descent, for which all prenatally stressed pups showed a 1-day delay in comparison with control rats, regardless of the postnatal adoption procedure. Levels of dopamine (DA) D-2 and glutamate (Glu) N-methyl-D-aspartate (NMDA) receptors were differentially regulated in different forebrain regions of cross-fostered adult offspring. Increased concentrations of cortical D2 receptors detected in stressed pups, raised by a gestationally stressed biological mother, were not detected when the pups were raised by a control mother. Control pups raised by a foster mother whether gestationally stressed or not had higher levels of NMDA receptors in cortical areas. These findings suggest that the normal expression of DA and Glu receptors is influenced by in utero experience and by lactation. The complex pattern of receptor changes reflects the high vulnerability of DA and Glu systems to variations both in prenatal and in postnatal environment, particularly for cortical D-2 receptors and NMDA receptors in cerebral cortex and nucleus accumbens. In contrast, testis descent appears to be more susceptible to prenatal than to postnatal environmental events. (C) 2004 Wiley-Liss, Inc.
引用
收藏
页码:488 / 496
页数:9
相关论文
共 49 条
[1]   Parent-offspring coadaptation and the dual genetic control of maternal care [J].
Agrawal, AF ;
Brodie, ED ;
Brown, J .
SCIENCE, 2001, 292 (5522) :1710-1712
[2]   Motor lateralization, behavioral despair and dopaminergic brain asymmetry after prenatal stress [J].
Alonso, SJ ;
Navarro, E ;
Santana, C ;
Rodriguez, M .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1997, 58 (02) :443-448
[3]  
Baldessarini RJ, 2001, GOODMAN GILMANS PHAR, P485, DOI DOI 10.1002/hup.540
[4]  
Barbazanges A, 1996, J NEUROSCI, V16, P7783
[5]   Corticosterone down-regulates dopamine D4 receptor in a mouse cerebral cortex neuronal cell line [J].
Barros, VG ;
Boado, LA ;
Adamo, AM ;
Caviedes, R ;
Caviedes, P ;
Antonelli, MC .
NEUROTOXICITY RESEARCH, 2003, 5 (05) :369-373
[6]  
BARROS VG, 2002, POSTNATAL ONTOGENY R
[7]   Emerging principles of altered neural circuitry in schizophrenia [J].
Benes, FM .
BRAIN RESEARCH REVIEWS, 2000, 31 (2-3) :251-269
[8]   Long-term effects of prenatal stress on dopamine and glutamate receptors in adult rat brain [J].
Berger, MA ;
Barros, VG ;
Sarchi, MI ;
Tarazi, FI ;
Antonelli, MC .
NEUROCHEMICAL RESEARCH, 2002, 27 (11) :1525-1533
[9]   Corticosterone administration to rat pups, but not maternal separation, affects sexual maturation and glucocorticoid receptor immunoreactivity in the testis [J].
Biagini, G ;
Pich, EM .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2002, 73 (01) :95-103
[10]   EFFECTS OF ADRENALECTOMY AND GLUCOCORTICOIDS ON RAT-BRAIN DOPAMINE-RECEPTORS [J].
BIRON, D ;
DAUPHIN, C ;
DIPAOLO, T .
NEUROENDOCRINOLOGY, 1992, 55 (04) :468-476