The hunchback and its neighbours: proline as an environmental modulator

被引：118

作者：

Reiersen, H

Rees, AR

机构：

[1] Affitech AS, N-0349 Oslo, Norway

[2] Univ Bath, Ctr Prot Anal & Design, Bath BA2 7AY, Avon, England

[3] Syntem, F-30000 Nimes, France

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 11期

关键词：

D O I：

10.1016/S0968-0004(01)01957-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The unique ability of Pro or Pro-rich repeats to affect the stability and function of proteins has recently been highlighted by biophysical studies on fragments from prions, signalling domains and muscle proteins. Pro-rich regions have been observed to either occupy disordered states or adopt various helical structures; some are also able to undergo an environmental-dependent transformation between these states. Such a transformation could explain some of the inherent functional properties of the parent proteins and, additionally, can be efficiently exploited to generate novel temperature- and pH-switches in more conventional globular proteins.

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页码：679 / 684

页数：6

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