Palladium-catalyzed intramolecular cyclization of o-ethynylbenzoic acids and o-ethynylbenzamides:: Preparation of isocoumarins and isoquinolin-1-ones

被引:134
作者
Sashida, H [1 ]
Kawamukai, A [1 ]
机构
[1] Hokuriku Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9201181, Japan
来源
SYNTHESIS-STUTTGART | 1999年 / 07期
关键词
o-ethynylbenzoic acid; o-ethynylbenzamide; 6-endo-dig cyclization; isocoumarin; isoquinolin-1-one;
D O I
10.1055/s-1999-3522
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Treatment of the o-ethynylbenzoic acids 1A with a catalytic amount of Pd(II) and triethylamine resulted in the 6-endo-dig cyclization to give the 3-substituted isocoumarins 3 as major products in moderate to good yields. Similarly, the palladium-catalyzed cyclization of o-ethynylbenzamides 1B also proceeded but afforded only the isoquinolin-1-ones 3B.
引用
收藏
页码:1145 / 1148
页数:4
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