Enhanced DNA photocleavage and binding properties of sapphyrin-polyamine conjugates

被引：19

作者：

Sessler, JL

Andrievsky, A

Sansom, PI

Kral, V

Iverson, BL

机构：

[1] Dept. of Chemistry and Biochemistry, University of Texas at Austin, Austin

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(97)00237-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of several water-soluble sapphyrin derivatives is described. Of these, the sapphyrins 2-4, bearing appended polyamines, exhibit enhanced DNA photocleavage and binding over sapphyrin 1 as determined from pBR322 plasmid cleavage experiments and an ethidium bromide displacement fluorescence assay. (C) 1997 Elsevier Science Ltd.

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收藏

页码：1433 / 1436

页数：4

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