Nitric oxide and the renin-angiotensin system.: Is there a physiological interplay between the systems?

被引：28

作者：

Fernández-Alfonso, MS

González, C

机构：

[1] Univ Complutense Madrid, Fac Farm, Dept Farmacol, E-28040 Madrid, Spain

[2] Univ Complutense Madrid, Fac Med, Dept Fisiol, E-28040 Madrid, Spain

来源：

JOURNAL OF HYPERTENSION | 1999年 / 17卷 / 10期

关键词：

nitric oxide; eNOS; iNOS; angiotensin II; angiotensin-(1-7); angiotensin-converting enzyme; AT(1) receptors; AT(2) receptors; L-NAME-induced hypertension; neointima;

D O I：

10.1097/00004872-199917100-00001

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Opposed actions for nitric oxide (NO) and angiotensin II (Ang II) in vascular contraction and vascular smooth muscle cell proliferation and apoptosis are well documented. In addition, various experimental approaches have shown that NO negatively modulates the renin-angiotensin system by inhibiting angiotensin-converting enzyme (ACE) activity and down-regulating AT(1) receptors, On the other hand, Ang II and Ang-(1-7) positively stimulate NO synthesis and release, In this review, we analyse the data suggesting a mutual regulation between the renin-angiotensin and the nitric oxide-generating systems, and we propose a homeostatic interplay between both factors aimed at regulating cardiovascular function. J Hypertens 1999, 17:1355-1361 (C) Lippincott Williams & Wilkins.

引用

页码：1355 / 1361

页数：7

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