Highly active palladium catalysts for Suzuki coupling reactions

被引：1092

作者：

Wolfe, JP ^{[1
]}

Singer, RA ^{[1
]}

Yang, BH ^{[1
]}

Buchwald, SL ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1999年 / 121卷 / 41期

关键词：

D O I：

10.1021/ja992130h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mixtures of palladium acetate and o-(di-tert-butylphosphino)biphenyl (4) catalyze the room-temperature Suzuki coupling of aryl bromides and aryl chlorides with 0.5-1.0 mol % Pd. Use of o-dicyclohexylphosphino)biphenyl (2) allows Suzuki couplings to be:carried out:at law catalyst loadings (0.000001-0.02 mol % Pd). The process tolerates a broad range of functional groups:and substrate combinations including the use of sterically hindered substrates. This is the most active Catalyst systeminterms of reaction temperature, turnover number, and steric tolerance which has been reported to date.

引用

页码：9550 / 9561

页数：12

共 65 条

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