In vivo antitumor activity of chitosan nanoparticles

被引：121

作者：

Qi, Lifeng ^{[1
]}

Xu, Zirong

机构：

[1] Zhejiang Univ, Nanobiol Lab, Anim Sci Coll, Hangzhou 310029, Peoples R China

[2] W Virginia Univ, Sch Med, Dept Orthopaed, Orthopaed Res Lab, Morgantown, WV 26506 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 16期

关键词：

chitosan nanoparticles; in vivo antitumor; S-180; H22;

D O I：

10.1016/j.bmcl.2006.05.078

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chitosan nanoparticles have been synthesized as potential anticancer agents, and evaluated, in vitro, against various cancer cell lines. In this study, in vivo antitumor activity of chitosan nanoparticles against Sarcoma-180 and mouse hepatoma H22 was investigated. Chitosan nanoparticles showed significant antitumor activity in vivo. The doses and particle size made a great effect on their efficacy. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4243 / 4245

页数：3

共 20 条

[1] Development of superparamagnetic nanoparticles for MRI: Effect of particle size, charge and surface nature on biodistribution [J].

Chouly, C ;

Pouliquen, D ;

Lucet, I ;

Jeune, JJ ;

Jallet, P .

JOURNAL OF MICROENCAPSULATION, 1996, 13 (03) :245-255

[2] Chitosan nanoparticles:: a new vehicle for the improvement of the delivery of drugs to the ocular surface.: Application to cyclosporin A [J].

De Campos, AM ;

Sánchez, A ;

Alonso, MJ .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2001, 224 (1-2) :159-168

[3] Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A [J].

El-Shabouri, MH .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 249 (1-2) :101-108

[4] Chemotherapeutic engineering: Application and further development of chemical engineering principles for chemotherapy of cancer and other diseases [J].

Feng, SS ;

Chien, S .

CHEMICAL ENGINEERING SCIENCE, 2003, 58 (18) :4087-4114

[5] The oral absorption of micro- and nanoparticulates: Neither exceptional nor unusual [J].

Florence, AT .

PHARMACEUTICAL RESEARCH, 1997, 14 (03) :259-266

[6] Chitosan nanoparticles as delivery systems for doxorubicin [J].

Janes, KA ;

Fresneau, MP ;

Marazuela, A ;

Fabra, A ;

Alonso, MJ .

JOURNAL OF CONTROLLED RELEASE, 2001, 73 (2-3) :255-267

[7]

KONDO N, 1993, BIOL PHARM BULL, V16, P796

[8] PERORAL ADMINISTRATION OF NANOPARTICLES [J].

KREUTER, J .

ADVANCED DRUG DELIVERY REVIEWS, 1991, 7 (01) :71-86

[9] PARTICLE-SIZE REDUCTION FOR IMPROVEMENT OF ORAL BIOAVAILABILITY OF HYDROPHOBIC DRUGS .1. ABSOLUTE ORAL BIOAVAILABILITY OF NANOCRYSTALLINE DANAZOL IN BEAGLE DOGS [J].

LIVERSIDGE, GG ;

CUNDY, KC .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1995, 125 (01) :91-97

[10]

Moghimi SM, 2001, PHARMACOL REV, V53, P283

← 1 2 →