Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways

被引：892

作者：

Fearon, Kenneth C. H. ^{[1
]}

Glass, David J. ^{[2
]}

Guttridge, Denis C. ^{[3
]}

机构：

[1] Univ Edinburgh, Royal Infirm, Sch Clin Sci & Community Hlth, Edinburgh EH16 4SA, Midlothian, Scotland

[2] Novartis Inst Biomed Res, Cambridge, MA 02139 USA

[3] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

来源：

CELL METABOLISM | 2012年 / 16卷 / 02期

关键词：

SKELETAL-MUSCLE ATROPHY; TUMOR-NECROSIS-FACTOR; ACUTE-PHASE RESPONSE; UBIQUITIN LIGASE ATROGIN1/MAFBX; ADIPOSE TRIGLYCERIDE LIPASE; PROTEOLYSIS INDUCING FACTOR; FOXO TRANSCRIPTION FACTORS; SYNTHASE KINASE 3-BETA; MESSENGER-RNA LEVELS; KAPPA-B ACTIVATION;

D O I：

10.1016/j.cmet.2012.06.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cancer cachexia is characterized by a significant reduction in body weight resulting predominantly from loss of adipose tissue and skeletal muscle. Cachexia causes reduced cancer treatment tolerance and reduced quality and length of life, and remains an unmet medical need. Therapeutic progress has been impeded, in part, by the marked heterogeneity of mediators, signaling, and metabolic pathways both within and between model systems and the clinical syndrome. Recent progress in understanding conserved, molecular mechanisms of skeletal muscle atrophy/hypertrophy has provided a downstream platform for circumventing the variations and redundancy in upstream mediators and may ultimately translate into new targeted therapies.

引用

页码：153 / 166

页数：14

共 179 条

[1] Dystrophin glycoprotein complex dysfunction: A regulatory link between muscular dystrophy and cancer cachexia
Acharyya, S
Butchbach, MER
Sahenk, Z
Wang, HT
Saji, M
Carathers, M
Ringel, MD
Skipworth, RJE
Fearon, KCH
Hollingsworth, MA
Muscarella, P
Burghes, AHM
Rafael-Fortney, JA
Guttridge, DC
[J]. CANCER CELL, 2005, 8 (05) : 421 - 432
[2] Mechanisms for skeletal muscle insulin resistance in patients with pancreatic ductal adenocarcinoma
Agustsson, Thorhallur
D'souza, Melroy A.
Nowak, Greg
Isaksson, Bengt
[J]. NUTRITION, 2011, 27 (7-8) : 796 - 801
[3] Cutaneous castleman's disease responds to anti-interleukin-6 treatment
Ahmed, Bilal
Tschen, Jaime A.
Cohen, Philip R.
Zaki, Mohamed H.
Rady, Peter L.
Tyring, Stephen K.
Corringham, Robert E.
Kurzrock, Razelle
[J]. MOLECULAR CANCER THERAPEUTICS, 2007, 6 (09) : 2386 - 2390
[4] Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders
Aoki, Y
Yarchoan, R
Wyvill, K
Okamoto, S
Little, RF
Tosato, G
[J]. BLOOD, 2001, 97 (07) : 2173 - 2176
[5] Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1α and oxidative phosphorylation
Arany, Zoltan
Wagner, Bridget K.
Ma, Yanhong
Chinsomboon, Jessica
Laznik, Dina
Spiegelman, Bruce M.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (12) : 4721 - 4726
[6] Evidence for the contribution of insulin resistance to the development of cachexia in tumor-bearing mice
Asp, Michelle L.
Tian, Min
Wendel, Angela A.
Belury, Martha A.
[J]. INTERNATIONAL JOURNAL OF CANCER, 2010, 126 (03) : 756 - 763
[7] MAFbx/Atrogin-1 expression is a poor index of muscle proteolysis
Attaix, Didier
Baracos, Vickie E.
[J]. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2010, 13 (03) : 223 - 224
[8] Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1
Baar, K
Wende, AR
Jones, TE
Marison, M
Nolte, LA
Chen, M
Kelly, DP
Holloszy, JO
[J]. FASEB JOURNAL, 2002, 16 (14) : 1879 - 1886
[9] Fas receptor signaling inhibits glycogen synthase kinase 3β and induces cardiac hypertrophy following pressure overload
Badorff, C
Ruetten, H
Mueller, S
Stahmer, M
Gehring, D
Jung, F
Ihling, C
Zeiher, AM
Dimmeler, S
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (03) : 373 - 381
[10] Interleukin-6 and cachexia in ApcMin/+ mice
Baltgalvis, Kristen A.
Berger, Franklin G.
Pena, Maria Marjorette O.
Davis, J. Mark
Muga, Stephanie J.
Carson, James A.
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2008, 294 (02) : R393 - R401

← 1 2 3 4 5 6 7 8 9 10 →