No evidence for association between polymorphisms in GRM3 and schizophrenia

被引：40

作者：

Norton, Nadine ^{[1
]}

Williams, Hywel J. ^{[1
]}

Dwyer, Sarah ^{[1
]}

Ivanov, Dobril ^{[1
]}

Preece, Anna C. ^{[1
]}

Gerrish, Amy ^{[1
]}

Williams, Nigel M. ^{[1
]}

Yerassimou, Pamela ^{[1
]}

Zammit, Stanley ^{[1
]}

O'Donovan, Michael C. ^{[1
]}

Owen, Michael J. ^{[1
]}

机构：

[1] Cardiff Univ, Wales Sch Med, Dept Psychol Med, Cardiff, S Glam, Wales

来源：

BMC PSYCHIATRY | 2005年 / 5卷 / 1期

基金：

英国医学研究理事会;

关键词：

Schizophrenia; Linkage Disequilibrium; Hapmap Database; Caucasian Sample; Marker Haplotype;

D O I：

10.1186/1471-244X-5-23

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3. Methods: In a bid to examine this hypothesis, we examined seven SNPs spanning GRM3 in a UK case-control sample (schizophrenic cases n = 674, controls n = 716). These included all SNPs previously reported to be associated, alone or in haplotypes, with schizophrenia in European or European American samples. Results: Our data showed no evidence for association with single markers, or 2, 3, 4 and 5 marker haplotypes, nor did any specific haplotypes show evidence for association according to previously observed patterns. Conclusion: Examination of our own data and those of other groups leads us to conclude that at present, GRM3 should not be viewed as a gene for which there is replicated evidence for association with schizophrenia.

引用

页数：6

共 17 条

[1] GOLD - Graphical Overview of Linkage Disequilibrium [J].

Abecasis, GR ;

Cookson, WOC .

BIOINFORMATICS, 2000, 16 (02) :182-183

[2] Association study designs for complex diseases [J].

Cardon, LR ;

Bell, JI .

NATURE REVIEWS GENETICS, 2001, 2 (02) :91-99

[3] A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese population [J].

Chen, Q ;

He, G ;

Chen, QY ;

Wu, SN ;

Xu, YF ;

Feng, GY ;

Li, YC ;

Wang, LJ ;

He, L .

SCHIZOPHRENIA RESEARCH, 2005, 73 (01) :21-26

[4] Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia [J].

Egan, MF ;

Straub, RE ;

Goldberg, TE ;

Yakub, I ;

Callicott, JH ;

Hariri, AR ;

Mattay, VS ;

Bertolino, A ;

Hyde, TM ;

Shannon-Weickert, C ;

Akil, M ;

Crook, J ;

Vakkalanka, RK ;

Balkissoon, R ;

Gibbs, RA ;

Kleinman, JE ;

Weinberger, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (34) :12604-12609

[5] Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia [J].

Fujii, Y ;

Shibata, H ;

Kikuta, R ;

Makina, C ;

Tani, A ;

Hirata, N ;

Shibata, A ;

Ninomiya, H ;

Tashiro, N ;

Fukumaki, Y .

PSYCHIATRIC GENETICS, 2003, 13 (02) :71-76

[6] The structure of haplotype blocks in the human genome [J].

Gabriel, SB ;

Schaffner, SF ;

Nguyen, H ;

Moore, JM ;

Roy, J ;

Blumenstiel, B ;

Higgins, J ;

DeFelice, M ;

Lochner, A ;

Faggart, M ;

Liu-Cordero, SN ;

Rotimi, C ;

Adeyemo, A ;

Cooper, R ;

Ward, R ;

Lander, ES ;

Daly, MJ ;

Altshuler, D .

SCIENCE, 2002, 296 (5576) :2225-2229

[7] Glutamate in schizophrenia: clinical and research implications [J].

Goff, DC ;

Wine, L .

SCHIZOPHRENIA RESEARCH, 1997, 27 (2-3) :157-168

[8] Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence [J].

Harrison, PJ ;

Weinberger, DR .

MOLECULAR PSYCHIATRY, 2005, 10 (01) :40-68

[9]

JAVITT DC, 1991, AM J PSYCHIAT, V148, P1301

[10] LOW CEREBROSPINAL-FLUID GLUTAMATE IN SCHIZOPHRENIC-PATIENTS AND A NEW HYPOTHESIS ON SCHIZOPHRENIA [J].

KIM, JS ;

KORNHUBER, HH ;

SCHMIDBURGK, W ;

HOLZMULLER, B .

NEUROSCIENCE LETTERS, 1980, 20 (03) :379-382

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