Priming stimulation in the basolateral amygdala modulates synaptic plasticity in the rat dentate gyrus

被引：52

作者：

Akirav, I ^{[1
]}

Richter-Levin, G ^{[1
]}

机构：

[1] Univ Haifa, Dept Psychol, Lab Behav Neurosci, IL-31905 Haifa, Israel

来源：

NEUROSCIENCE LETTERS | 1999年 / 270卷 / 02期

关键词：

memory; basolateral amygdala; hippocampus; dentate gyrus; long-term potentiation; amygdalo-hippocampal interaction; synaptic plasticity; rat;

D O I：

10.1016/S0304-3940(99)00488-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the effects of basolateral amygdala (BLA) priming on long-term potentiation (LTP) in the dentate gyrus (DG). In the control animals, the induction of high-frequency stimulation (HFS) to the perforant path (PP) resulted in hippocampal LTP at all the time intervals tested. A priming stimulation to the BLA prior to the application of HFS to the PP resulted in the enhancement of the excitatory post-synaptic potential (EPSP)-LTP and population spike (PS)-LTP in the DG from 90-min post-HFS onwards. These findings suggest that the amygdala has a potential role in the modulation of some aspects of memory that are mediated by the hippocampus. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：83 / 86

页数：4

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