Effects of long-term renal sympathetic denervation on heart failure after myocardial infarction in rats

被引：93

作者：

Nozawa, T ^{[1
]}

Igawa, A ^{[1
]}

Fujii, N ^{[1
]}

Kato, B ^{[1
]}

Yoshida, N ^{[1
]}

Asanoi, H ^{[1
]}

Inoue, F ^{[1
]}

机构：

[1] Toyama Med & Pharmaceut Univ, Dept Internal Med 2, Sugitani, Toyama 9300194, Japan

来源：

HEART AND VESSELS | 2002年 / 16卷 / 02期

关键词：

myocardial infarction; sympathetic nerve activity; kidney; heart failure; natriuresis;

D O I：

10.1007/s380-002-8317-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The purpose of the present study was to investigate the effects of long-term renal denervation (RD) on heart failure due to myocardial infarction (MI). Wistar rats were anesthetized and the bilateral renal nerves were surgically denervated 2 days before MI was induced by coronary artery ligation. Four weeks later, left ventricular (LV) function and sodium excretion were determined. In MI rats, RD improved the reduced sodium excretion. MI + RD rats revealed lower LV end-diastolic pressure and greater maximum dP/dt as compared with those of MI+ innervation (INN) rats. LV end-diastolic and end-systolic dimensions were significantly smaller and LV fractional shortening was greater in MI + RD rats than in MI + INN rats (20.9% +/- 3.2% vs 14.9% +/- 3.0%). In rats without MI, RD did not affect either sodium excretion or LV function and dimensions. The present results suggest that the long-term RD reduces LV filling pressure and improves LV function after MI, probably due to a restoration of impaired natriuresis. Increased renal sympathetic nerve activity might contribute to the progression of heart failure after MI.

引用

页码：51 / 56

页数：6

共 36 条

[1] RENAL SYMPATHETIC-NERVES MODULATE GLOMERULAR ANP RECEPTORS AND FILTRATION [J].

AWAZU, M ;

KON, V ;

HARRIS, RC ;

IMADA, T ;

INAGAMI, T ;

ICHIKAWA, I .

AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 261 (01) :F29-F35

[2] Reducing cardiac filling pressure lowers norepinephrine spillover in patients with chronic heart failure [J].

Azevedo, ER ;

Newton, GE ;

Floras, JS ;

Parker, JD .

CIRCULATION, 2000, 101 (17) :2053-2059

[3] EFFECT OF VASODILATOR THERAPY ON MORTALITY IN CHRONIC CONGESTIVE-HEART-FAILURE - RESULTS OF A VETERANS-ADMINISTRATION COOPERATIVE STUDY [J].

COHN, JN ;

ARCHIBALD, DG ;

ZIESCHE, S ;

FRANCIOSA, JA ;

HARSTON, WE ;

TRISTANI, FE ;

DUNKMAN, WB ;

JACOBS, W ;

FRANCIS, GS ;

FLOHR, KH ;

GOLDMAN, S ;

COBB, FR ;

SHAH, PM ;

SAUNDERS, R ;

FLETCHER, RD ;

LOEB, HS ;

HUGHES, VC ;

BAKER, B .

NEW ENGLAND JOURNAL OF MEDICINE, 1986, 314 (24) :1547-1552

[4] Effect of metoprolol administration on renal sodium handling in experimental congestive heart failure [J].

DiBona, GF ;

Sawin, LL .

CIRCULATION, 1999, 100 (01) :82-86

[5] ROLE OF RENAL NERVES IN SODIUM RETENTION OF CIRRHOSIS AND CONGESTIVE-HEART-FAILURE [J].

DIBONA, GF ;

SAWIN, LL .

AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (02) :R298-R305

[6] NEURAL CONTROL OF RENAL-FUNCTION IN EDEMA-FORMING STATES [J].

DIBONA, GF ;

HERMAN, PJ ;

SAWIN, LL .

AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 254 (06) :R1017-R1024

[7] Cardiac sympathetic nerve function in congestive heart failure [J].

Eisenhofer, G ;

Friberg, P ;

Rundqvist, B ;

Quyyumi, AA ;

Lambert, G ;

Kaye, DM ;

Kopin, IJ ;

Goldstein, DS ;

Esler, MD .

CIRCULATION, 1996, 93 (09) :1667-1676

[8] CHARACTERISTICS OF RENAL SYMPATHETIC-NERVE ACTIVITY IN EXPERIMENTAL CONGESTIVE-HEART-FAILURE IN THE RAT [J].

FENG, QP ;

CARLSSON, S ;

THOREN, P ;

HEDNER, T .

ACTA PHYSIOLOGICA SCANDINAVICA, 1994, 150 (03) :259-266

[9]

FENG QP, 1992, J PHARMACOL EXP THER, V261, P1129

[10] RENAL DENERVATION AND CATECHOLAMINES OF CENTRAL NERVOUS-SYSTEM [J].

FERNANDEZ, BE ;

DOMINGUEZ, AE ;

VIDAL, NA ;

TAQUINI, AC .

NEUROENDOCRINOLOGY, 1974, 15 (06) :338-345

← 1 2 3 4 →