Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn's and Colitis Epidemiology Study

被引：750

作者：

Ng, Siew C. ^{[1
]}

Tang, Whitney ^{[1
]}

Ching, Jessica Y. ^{[1
]}

Wong, May ^{[1
]}

Chow, Chung Mo ^{[2
]}

Hui, A. J. ^{[3
]}

Wong, T. C. ^{[4
]}

Leung, Vincent K. ^{[5
]}

Tsang, Steve W. ^{[6
]}

Yu, Hon Ho ^{[7
]}

Li, Mo Fong ^{[7
]}

Ng, Ka Kei ^{[8
]}

Kamm, Michael A. ^{[9
,10
]}

Studd, Corrie ^{[9
,10
]}

Bell, Sally ^{[9
,10
]}

Leong, Rupert ^{[11
]}

de Silva, H. Janaka ^{[12
]}

Kasturiratne, Anuradhani ^{[12
]}

Mufeena, M. N. F. ^{[12
]}

Ling, Khoon Lin ^{[13
]}

Ooi, Choon Jin ^{[13
]}

Tan, Poh Seng ^{[14
]}

Ong, David ^{[14
]}

Goh, Khean L. ^{[15
]}

Hilmi, Ida ^{[15
]}

Pisespongsa, Pises ^{[16
]}

Manatsathit, Sathaporn ^{[17
]}

Rerknimitr, Rungsun ^{[18
]}

Aniwan, Satimai ^{[18
]}

Wang, Yu Fang ^{[19
]}

Ouyang, Qin ^{[19
]}

Zeng, Zhirong ^{[20
]}

Zhu, Zhenhua ^{[20
]}

Chen, Min Hu ^{[20
]}

Hu, Pin Jin ^{[20
]}

Wu, Kaichun ^{[21
]}

Wang, Xin ^{[21
]}

Simadibrata, Marcellus ^{[22
]}

Abdullah, Murdani ^{[22
]}

Wu, Justin Cy ^{[1
]}

Sung, Joseph J. Y. ^{[1
]}

Chan, Francis K. L. ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Dept Med & Therapeut, Inst Digest Dis, Li Ka Shing Inst Hlth Sci, Hong Kong, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Dept Pediat, Hong Kong, Hong Kong, Peoples R China

[3] Alice Ho Miu Ling Nethersole Hosp, Hong Kong, Peoples R China

[4] North Dist Hosp, Hong Kong, Hong Kong, Peoples R China

[5] United Christian Hosp, Hong Kong, Hong Kong, Peoples R China

[6] Tseung Kwan O Hosp, Hong Kong, Hong Kong, Peoples R China

[7] Kiangwu Hosp, Macao, Peoples R China

[8] Hosp Conde S Januario, Macao, Peoples R China

[9] St Vincent Hosp, Melbourne, Vic, Australia

[10] Univ Melbourne, Melbourne, Vic, Australia

[11] Bankstown & Concord Hosp, Sydney, NSW, Australia

[12] Univ Kelaniya, Fac Med, Ragama, Sri Lanka

[13] Singapore Gen Hosp, Singapore, Singapore

[14] Natl Univ Singapore Hosp, Singapore 117548, Singapore

[15] Univ Malaya, Med Ctr, Kuala Lumpur, Malaysia

[16] Maharaj Nakorn Chiangmai Hosp, Chiangmai, Thailand

[17] Siriraj Hosptial, Bangkok, Thailand

[18] King Chulalongkorn Mem Hosp, Bangkok, Thailand

[19] Sichuan Univ, West China Hosp, Chengdu 610064, Peoples R China

[20] San Yat Sen Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China

[21] Fourth Mil Med Univ, Xijing Hosp, Dept Gastroenterol, Xian, Shaanxi, Peoples R China

[22] Univ Indonesia, Depok, Indonesia

来源：

GASTROENTEROLOGY | 2013年 / 145卷 / 01期

关键词：

ACCESS; Intestine; Inflammation; Rate; ULCERATIVE-COLITIS; CLINICAL CHARACTERISTICS; RISK-FACTORS; POPULATION; PREVALENCE; CHINA; COPENHAGEN; COUNTY; MANIFESTATIONS; CLASSIFICATION;

D O I：

10.1053/j.gastro.2013.04.007

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BACKGROUND & AIMS: Inflammatory bowel diseases (IBD) are becoming more common in Asia, but epidemiologic data are lacking. The Asia-Pacific Crohn's and Colitis Epidemiology Study aimed to determine the incidence and phenotype of IBD in 8 countries across Asia and in Australia. METHODS: We performed a prospective, population-based study of IBD incidence in pre-defined catchment areas, collecting data for 1 year, starting on April 1, 2011. New cases were ascertained from multiple overlapping sources and entered into a Web-based database. Cases were confirmed using standard criteria. Local endoscopy, pathology, and pharmacy records were searched to ensure completeness of case capture. RESULTS: We identified 419 new cases of IBD (232 of ulcerative colitis [UC], 166 of Crohn's disease [CD], and 21 IBD-undetermined). The crude annual overall incidence values per 100,000 individuals were 1.37 for IBD in Asia (95% confidence interval: 1.25-1.51; 0.76 for UC, 0.54 for CD, and 0.07 for IBD-undetermined) and 23.67 in Australia (95% confidence interval: 18.46-29.85; 7.33 for UC, 14.00 for CD, and 2.33 for IBD-undetermined). China had the highest incidence of IBD in Asia (3.44 per 100,000 individuals). The ratios of UC to CD were 2.0 in Asia and 0.5 in Australia. Median time from symptom onset to diagnosis was 5.5 months (interquartile range, 1.4-15 months). Complicated CD (stricturing, penetrating, or perianal disease) was more common in Asia than Australia (52% vs 24%; P = .001), and a family history of IBD was less common in Asia (3% vs 17%; P < .001). CONCLUSIONS: We performed a large-scale population-based study and found that although the incidence of IBD varies throughout Asia, it is still lower than in the West. IBD can be as severe or more severe in Asia than in the West. The emergence of IBD in Asia will result in the need for specific health care resources, and offers a unique opportunity to study etiologic factors in developing nations.

引用

页码：158 / +

页数：10

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