Papillomavirus-like particle vaccines for cervical cancer

被引：60

作者：

Schiller, JT ^{[1
]}

机构：

[1] NCI, Cellular Oncol Lab, Bethesda, MD 20892 USA

来源：

MOLECULAR MEDICINE TODAY | 1999年 / 5卷 / 05期

关键词：

D O I：

10.1016/S1357-4310(99)01463-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Most cervical cancers are now known to be caused by human papillomavirus (HPV) infections. This provides an opportunity to prevent a major cause of cancer deaths in women through vaccination. Subunit vaccines based upon non-infectious papillomavirus-like particles (VLPs) are attractive candidates to prevent infection by oncogenic HPVs, anal clinical trials are now underway in addition, the strongly immunogenic characteristics of VLPs raise the possibility that they could also serve as vehicles for inducing therapeutic responses against HPV-induced neoplasia and other diseases.

引用

页码：209 / 215

页数：7

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