Correlation Between IL-10 Gene Expression and HPV Infection in Cervical Cancer: A Mechanism for Immune Response Escape

被引：87

作者：

Bermudez-Morales, Victor H. ^{[1
,2
]}

Gutierrez, Lourdes X. ^{[1
]}

Alcocer-Gonzalez, Juan M. ^{[3
]}

Burguete, Ana ^{[1
]}

Madrid-Marina, Vicente ^{[1
,2
]}

机构：

[1] Natl Inst Publ Hlth, Div Mol Biol Pathogens, Cuernavaca 62508, Morelos, Mexico

[2] Univ Nacl Autonoma Mexico, Sch Med, Mexico City 04510, DF, Mexico

[3] Autonomous Univ Nuevo Leon, Sch Biol Sci, Mexico City, DF, Mexico

来源：

CANCER INVESTIGATION | 2008年 / 26卷 / 10期

关键词：

HPV; IL-10; Immunosuppression; Cervical cancer;

D O I：

10.1080/07357900802112693

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The present study was performed to determine IL-10 expression in cervical tissues in Mexican women according to the severity of the malignity and its association with HPV infection. IL-10 expression showed a clear tendency to increase during the different cervical cancer stages: 37% in LGSIL; 62% in HGSIL; and 84% in cancer. However, all the patients that expressed IL-10 were HPV positives; we found an association with HPV 16. These results suggest a clear relationship between IL-10, HPV and the stage of cervical cancer disease; this event could contribute to the immunosuppressive micro-environment in the tumor site.

引用

页码：1037 / 1043

页数：7

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