Prevalence and Genetic Characterization of blaCTX-M Among Klebsiella pneumoniae Isolates Collected in an Intensive Care Unit in Brazil

被引:11
作者
Filho, J. R. Do Carmo [2 ]
Silva, R. M. [3 ]
Castanheira, M. [1 ]
Tognim, M. C. B. [4 ]
Gales, A. C. [3 ]
Sader, H. S. [1 ,3 ]
机构
[1] JMI Labs, N Liberty, IA 52317 USA
[2] Pontificia Univ Catolica Goias, Goiania, Go, Brazil
[3] Univ Fed Sao Paulo, Sao Paulo, Brazil
[4] Univ Estadual Maringa, Maringa, Parana, Brazil
关键词
Klebsiella pneumoniae; extended-spectrum beta-lactamases; antimicrobial resistance; genetic resistance mechanisms;
D O I
10.1179/joc.2008.20.5.600
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Thirteen (44.8%) CTX-M-2-producing K. pneumoniae clinical isolates were identified among 29 strains collected from single patients with serious infection hospitalized in an intensive care unit of a tertiary hospital located in Sao Paulo, Brazil. These isolates belonged to 9 different typing clusters and showed great diversity of plasmid content. Their bla(CTX-M-2) was carried in an ISCR1/sul1-type integron structure located in transferable plasmids of different sizes or in the chromosome.
引用
收藏
页码:600 / 603
页数:4
相关论文
共 11 条
  • [1] Growing group of extended-spectrum β-lactamases:: The CTX-M enzymes
    Bonnet, R
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (01) : 1 - 14
  • [2] The CTX-M β-lactamase pandemic
    Canton, Rafael
    Coque, Teresa M.
    [J]. CURRENT OPINION IN MICROBIOLOGY, 2006, 9 (05) : 466 - 475
  • [3] Detection of extended-spectrum β-lactamases in klebsiellae with the oxoid combination disk method
    Carter, MW
    Oakton, KJ
    Warner, M
    Livermore, DM
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (11) : 4228 - 4232
  • [4] DNA sequence analysis of the genetic environment of various blaCTX-M genes
    Eckert, C
    Gautier, V
    Arlet, G
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 57 (01) : 14 - 23
  • [5] Extended-spectrum β-lactamases in multidrug-resistant Escherichia coli:: Changing the therapy for hospital-acquired and community-acquired infections
    Helfand, Marion S.
    Bonomo, Robert A.
    [J]. CLINICAL INFECTIOUS DISEASES, 2006, 43 (11) : 1415 - 1416
  • [6] CTX-M: changing the face of ESBLs in Europe
    Livermore, David M.
    Canton, Rafael
    Gniadkowski, Marek
    Nordmann, Patrice
    Rossolini, Gian Maria
    Arlet, Guillaume
    Ayala, Juan
    Coque, Teresa M.
    Kern-Zdanowicz, Izabela
    Luzzaro, Francesco
    Poirel, Laurent
    Woodford, Neil
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 59 (02) : 165 - 174
  • [7] Prevalence of community-occurring extended spectrum β-lactamase-producing Enterobacteriaceae in Brazil
    Minarini, Luciene A. R.
    Gales, Ana C.
    Palazzo, Izabel C. V.
    Darini, Ana Lucia C.
    [J]. CURRENT MICROBIOLOGY, 2007, 54 (05) : 335 - 341
  • [8] PFALLER MA, 1992, CLIN MICROBIOLOGY S, V1
  • [9] Sambrook J, 2001, Molecular Cloning: A Laboratory Manual
  • [10] Common regions e.g. orf513 and antibiotic resistance:: IS91-like elements evolving complex class 1 integrons
    Toleman, Mark A.
    Bennett, Peter M.
    Walsh, Timothy R.
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 58 (01) : 1 - 6