Interindividual differences in the perception of dental stimulation and related brain activity

被引:33
作者
Ettlin, D. A. [2 ]
Bruegger, M. [1 ]
Keller, T. [3 ]
Luechinger, R. [4 ]
Jaencke, L. [1 ]
Palla, S. [2 ]
Barlow, A. [5 ]
Gallo, L. M. [2 ]
Lutz, K. [1 ]
机构
[1] Univ Zurich, Inst Neuropsychol, Dept Psychol Neuropsychol, CH-8050 Zurich, Switzerland
[2] Univ Zurich, Ctr Dent & Oral Med & Cranio Maxillofacial Surg, Clin Removable Prosthodont Masticatory Disorders, CH-8050 Zurich, Switzerland
[3] Swiss Fed Inst Technol, Automat Control Lab, Zurich, Switzerland
[4] Swiss Fed Inst Technol, Inst Biomed Engn, Zurich, Switzerland
[5] GlaxoSmithKline Inc, Consumer Healthcare, Weybridge, Surrey, England
关键词
electric stimulation; magnetic resonance imaging; sensation and perception; tooth; toothache model; POSITRON-EMISSION-TOMOGRAPHY; ANTERIOR CINGULATE; PAIN; HUMANS; CORTEX; MODULATION; RESPONSES; METAANALYSIS; ACTIVATION; ANALGESIA;
D O I
10.1111/j.1600-0722.2008.00590.x
中图分类号
R78 [口腔科学];
学科分类号
100302 [口腔临床医学];
摘要
For identical diagnoses in the trigeminal innervation territory, individual differences have been clinically observed among the symptoms reported, such as dysesthesia and pain. Different subjective perceptions of unpleasantness and pain intensity may have different cortical substrates. The aim of this study was to identify brain areas in which activation depends on the subjective perception (intensity and unpleasantness) of electric dental stimulation. Electrical stimuli of increasing intensity were applied to maxillary canines in 14 healthy volunteers. Ratings for stimulus intensity and unpleasantness perceived across the stimulation session were reported postscan on 11-point numerical scales. The rating values were then included as covariates in the functional magnetic resonance imaging (fMRI) group analysis. Interindividual differences of intensity ratings were reflected in differential activity of the following brain areas: superior parietal lobule, superior temporal gyrus/anterior insula, inferior and middle temporal gyrus, lingual gyrus, anterior cingulate, and caudate nucleus. Differences related to unpleasantness ratings were reflected in the lingual gyrus. In conclusion, differences of perceived intensity between individuals are reflected in the differential activity of a set of brain areas distinct from those regions, reflecting rating differences of unpleasantness.
引用
收藏
页码:27 / 33
页数:7
相关论文
共 33 条
[1]
SENSATION EVOKED BY BIPOLAR INTRAPULPAL STIMULATION IN MAN [J].
AZERAD, J ;
WODA, A .
PAIN, 1977, 4 (02) :145-152
[2]
Imaging how attention modulates pain in humans using functional MRI [J].
Bantick, SJ ;
Wise, RG ;
Ploghaus, A ;
Clare, S ;
Smith, SM ;
Tracey, I .
BRAIN, 2002, 125 :310-319
[3]
Dissociable neural responses related to pain intensity, stimulus intensity, and stimulus awareness within the anterior cingulate cortex:: A parametric single-trial laser functional magnetic resonance imaging study [J].
Büchel, C ;
Bornhövd, K ;
Quante, M ;
Glauche, V ;
Bromm, B ;
Weiller, C .
JOURNAL OF NEUROSCIENCE, 2002, 22 (03) :970-976
[4]
Crossmodal processing in the human brain: Insights from functional neuroimaging studies [J].
Calvert, GA .
CEREBRAL CORTEX, 2001, 11 (12) :1110-1123
[5]
Canavan Dermot, 1994, Journal of Orofacial Pain, V8, P391
[6]
Clark Glenn T, 2008, Dent Clin North Am, V52, P183, DOI 10.1016/j.cden.2007.09.003
[7]
Neural correlates of interindividual differences in the subjective experience of pain [J].
Coghill, RC ;
McHaffie, JG ;
Yen, YF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (14) :8538-8542
[8]
Damasio Antonio R., 1994, Descartes' Error: Emotion, Reason, and the Human Brain
[9]
Cortical activation resulting from painless vibrotactile dental stimulation measured by functional magnetic resonance imaging (fMRI) [J].
Ettlin, DA ;
Zhang, H ;
Lutz, K ;
Järmann, T ;
Meier, D ;
Gallo, LM ;
Jäncke, L ;
Palla, S .
JOURNAL OF DENTAL RESEARCH, 2004, 83 (10) :757-761
[10]
Brain activity associated with painfully hot stimuli applied to the upper limb: A meta-analysis [J].
Farrell, MJ ;
Laird, AR ;
Egan, GF .
HUMAN BRAIN MAPPING, 2005, 25 (01) :129-139