Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system

被引：71

作者：

Okada, Taro ^{[1
]}

Kajimoto, Taketoshi ^{[1
]}

Jahangeer, Saleem ^{[1
]}

Nakamura, Shun-ichi ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Med, Div Biochem, Dept Biochem Mol Biol, Kobe, Hyogo 6500017, Japan

来源：

CELLULAR SIGNALLING | 2009年 / 21卷 / 01期

基金：

日本学术振兴会;

关键词：

Sphingosine; 1-phosphate; Sphingosine kinase; Neurotransmitter; Alzheimer's disease; Neuron; Central nervous system; Apoptosis; OPERATED CALCIUM-CHANNELS; PROTEIN-COUPLED RECEPTOR; FC-EPSILON-RI; CELL-DEATH; ALZHEIMERS-DISEASE; MOLECULAR-CLONING; KINASE TYPE-2; INTRACELLULAR SPHINGOSINE-1-PHOSPHATE; MEDIATED PHOSPHORYLATION; DEPENDENT REGULATION;

D O I：

10.1016/j.cellsig.2008.07.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sphingolipids were once regarded as inert structural components of cell membranes. Now these metabolites are generally believed to be important bioactive molecules that control a wide repertoire of cellular processes such as proliferation and survival of cells. Along with these ubiquitous cell functions observed in many peripheral tissues sphingolipid metabolites, especially sphingosine 1-phosphate, exert important neuron-specific functions such as regulation of neurotransmitter release. This review summarizes physiological and pathological roles of sphingolipid metabolites emphasizing the role of sphingosine 1-phosphate in the central nervous system. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：7 / 13

页数：7

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