Transient upregulation of osteopontin mRNA in hippocampus and striatum following global forebrain ischemia in rats

被引：57

作者：

Lee, MY

Shin, SL

Choi, YS

Kim, EJ

Cha, JH

Chun, MH

Lee, SB

Kim, SY

机构：

[1] Catholic Univ Korea, Coll Med, Dept Pharmacol, Socho Gu, Seoul 137701, South Korea

[2] Catholic Univ Korea, Coll Med, Dept Anat, Seoul 137701, South Korea

来源：

NEUROSCIENCE LETTERS | 1999年 / 271卷 / 02期

关键词：

osteopontin; forebrain ischemia; microglia; in situ hybridization; northern blot analysis; rat;

D O I：

10.1016/S0304-3940(99)00526-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the spatial and temporal expression of osteopontin (OPN) mRNA following transient forebrain ischemia in rats. Experiments were carried out using a four-vessel occlusion model for forebrain ischemia. The transient induction of OPN mRNA after global ischemia occurred earlier in the striatum than in the hippocampus. It was pronounced in the dorsomedial striatum close to the lateral ventricle and in the CA1subfield and the subiculum of the hippocampus before microglial cells became more reactive. It also could be detected in the dentate hilus and to a marginal extent in the CA3. Our results suggest that the hippocampus and the striatum following global forebrain ischemia upregulate OPN mRNA in different spatiotemporal profiles. (C)1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：81 / 84

页数：4

共 10 条

[1] Osteopontin and its integrin receptor αVβ3 are upregulated during formation of the glial scar after focal stroke [J].