Endogenous 5-HT inhibits firing activity of hippocampal CA1 pyramidal neurons during conditioned fear stress-induced freezing behavior through stimulating 5-HT1A receptors

被引:32
作者
Tada, K [1 ]
Kasamo, K [1 ]
Suzuki, T [1 ]
Matsuzaki, Y [1 ]
Kojima, T [1 ]
机构
[1] Nihon Univ, Sch Med, Dept Neuropsychiat, Tokyo 1738610, Japan
关键词
hippocampus; unit recording; unanesthetized; WAY-100635; PCPA;
D O I
10.1002/hipo.10178
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This study examines the activity of hippocampal CA(1) pyramidal neurons during conditioned fear stress (CFS)-induced freezing behavior in unanesthetized, unrestrained rats. The firing frequency of hippocampal CA(1) pyramidal neurons was significantly decreased when conditioned rats exhibited freezing behavior. Firing frequency returned to the baseline after freezing behavior disappeared. The selective 5-hydroxy-tryptamine (5-HT)(1A) antagonists, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl] ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide (WAY-100635), and N-tert-butyl-3-[4-(2-methoxyphenyl)piperazine-1-yl]-2-phenylpropamide (WAY-100135) and 5-HT depletion with parachlorophenylalanine (PCPA) completely abolished the decrease in firing frequency during CFS-induced freezing behavior. These results suggested that endogenous 5-HT inhibited the firing activity of hippocampal CA(1) pyramidal neurons during CFS-induced freezing behavior mainly through stimulating 5-HT1A receptors. (C) 2004 Wiley-Liss, Inc.
引用
收藏
页码:143 / 147
页数:5
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