Brain natriuretic peptide is a sensitive indicator of impaired left-ventricular function in elderly patients with cardiovascular disease

被引：31

作者：

Yamada, Y

Goto, J

Yokota, M

机构：

[1] NATL CHUBU HOSP,DIV CARDIOL,AICHI,JAPAN

[2] NATL INST LONGEV SCI,DEPT GERIATR RES,OBU,AICHI 474,JAPAN

[3] NAGOYA UNIV,SCH MED,DEPT CLIN LAB MED,NAGOYA,AICHI 466,JAPAN

来源：

CARDIOLOGY | 1997年 / 88卷 / 05期

关键词：

brain natriuretic peptide; elderly patients; prior myocardial infarction; dilated cardiomyopathy; valvular heart disease; essential hypertension;

D O I：

10.1159/000177368

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We studied the relation between the plasma concentration of brain natriuretic peptide (BNP) and echocardiographic findings to determine the sensitivity of BNP as an indicator of left-ventricular dysfunction in elderly patients with various cardiovascular diseases. The plasma concentration of BNP was positively correlated with left-ventricular end-diastolic and end-systolic dimensions (LVEDD and LVESD, respectively) and inversely correlated with the left-ventricular ejection fraction (LVEF) in patients with prior myocardial infarction, dilated cardiomyopathy, and valvular heart disease. The plasma concentration of BNP decreased significantly in association with an increase in LVEF and decreases in LVEDD and LVESD in patients with congestive heart failure following therapy. These observations indicate that the plasma concentration of BNP is a sensitive marker of impaired left-ventricular function in elderly patients with various cardiovascular diseases and may be useful for evaluating the improvement in left-ventricular function and the efficacy of therapy in patients with congestive heart failure.

引用

收藏

页码：401 / 407

页数：7

相关论文

共 15 条

[1] New insights into the cardiac natriuretic peptides [J].

Bonow, RO .

CIRCULATION, 1996, 93 (11) :1946-1950

[2] INCREASED PLASMA-LEVELS OF BRAIN NATRIURETIC PEPTIDE IN PATIENTS WITH ACUTE MYOCARDIAL-INFARCTION [J].

MORITA, E ;

YASUE, H ;

YOSHIMURA, M ;

OGAWA, H ;

JOUGASAKI, M ;

MATSUMURA, T ;

MUKOYAMA, M ;

NAKAO, K .

CIRCULATION, 1993, 88 (01) :82-91

[3] PLASMA BRAIN NATRIURETIC PEPTIDE AS AN INDICATOR FOR ANGIOTENSIN-CONVERTING-ENZYME INHIBITION AFTER MYOCARDIAL-INFARCTION [J].

MOTWANI, JG ;

MCALPINE, H ;

KENNEDY, N ;

STRUTHERS, AD .

LANCET, 1993, 341 (8853) :1109-1113

[4] BRAIN NATRIURETIC PEPTIDE AS A NOVEL CARDIAC HORMONE IN HUMANS - EVIDENCE FOR AN EXQUISITE DUAL NATRIURETIC PEPTIDE SYSTEM, ATRIAL-NATRIURETIC-PEPTIDE AND BRAIN NATRIURETIC PEPTIDE [J].

MUKOYAMA, M ;

NAKAO, K ;

HOSODA, K ;

SUGA, S ;

SAITO, Y ;

OGAWA, Y ;

SHIRAKAMI, G ;

JOUGASAKI, M ;

OBATA, K ;

YASUE, H ;

KAMBAYASHI, Y ;

INOUYE, K ;

IMURA, H .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (04) :1402-1412

[5] HUMAN BRAIN NATRIURETIC PEPTIDE, A NOVEL CARDIAC HORMONE [J].

MUKOYAMA, M ;

NAKAO, K ;

SAITO, Y ;

OGAWA, Y ;

HOSODA, K ;

SUGA, S ;

SHIRAKAMI, G ;

JOUGASAKI, M ;

IMURA, H .

LANCET, 1990, 335 (8692) :801-802

[6] AUGMENTED SECRETION OF BRAIN NATRIURETIC PEPTIDE IN ACUTE MYOCARDIAL-INFARCTION [J].

MUKOYAMA, M ;

NAKAO, K ;

OBATA, K ;

JOUGASAKI, M ;

YOSHIMURA, M ;

MORITA, E ;

HOSODA, K ;

SUGA, S ;

OGAWA, Y ;

YASUE, H ;

IMURA, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 180 (01) :431-436

[7] NATRIURETIC PEPTIDES AS CARDIAC HORMONES IN NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS - THE VENTRICLE IS A MAJOR SITE OF SYNTHESIS AND SECRETION OF BRAIN NATRIURETIC PEPTIDE [J].

OGAWA, Y ;

NAKAO, K ;

MUKOYAMA, M ;

HOSODA, K ;

SHIRAKAMI, G ;

ARAI, H ;

SAITO, Y ;

SUGA, S ;

JOUGASAKI, M ;

IMURA, H .

CIRCULATION RESEARCH, 1991, 69 (02) :491-500

[8] Plasma brain natriuretic peptide as an indicator of left ventricular systolic function and long-term survival after acute myocardial infarction - Comparison with plasma atrial natriuretic peptide and N-terminal proatrial natriuretic peptide [J].

Omland, T ;

Aakvaag, A ;

Bonarjee, VVS ;

Caidahl, K ;

Lie, RT ;

Nilsen, DWT ;

Sundsfjord, JA ;

Dickstein, K .

CIRCULATION, 1996, 93 (11) :1963-1969

[9] A NEW NATRIURETIC PEPTIDE IN PORCINE BRAIN [J].

SUDOH, T ;

KANGAWA, K ;

MINAMINO, N ;

MATSUO, H .

NATURE, 1988, 332 (6159) :78-81

[10] RECEPTOR SELECTIVITY OF NATRIURETIC PEPTIDE FAMILY, ATRIAL-NATRIURETIC-PEPTIDE, BRAIN NATRIURETIC PEPTIDE, AND C-TYPE NATRIURETIC PEPTIDE [J].

SUGA, SI ;

NAKAO, K ;

HOSODA, K ;

MUKOYAMA, M ;

OGAWA, Y ;

SHIRAKAMI, G ;

ARAI, H ;

SAITO, Y ;

KAMBAYASHI, Y ;

INOUYE, K ;

IMURA, H .

ENDOCRINOLOGY, 1992, 130 (01) :229-239