Lamotrigine in the treatment of bipolar depression

被引:47
作者
Bowden, CL
Mitchell, P
Suppes, T
机构
[1] Univ Texas, Hlth Sci Ctr, Dept Psychiat, San Antonio, TX 78284 USA
[2] Univ New S Wales, Fac Med, Sydney, NSW, Australia
[3] Univ Texas, SW Med Ctr, Dallas, TX USA
关键词
bipolar depression; lamotrigine; placebo-controlled trial; efficacy; tolerability;
D O I
10.1016/S0924-977X(99)00024-3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Several case reports and open studies have reported the efficacy of lamotrigine in bipolar depression. ii randomised placebo-controlled 7-week study comparing two doses of lamotrigine with placebo in 195 patients with moderate to severe bipolar depression has now been completed. Lamotrigine was superior to placebo after 3 weeks as assessed by changes in the Montgomery-Asberg Depression Rating Scale (MADRS). A response, defined as more than 50% improvement on the MADRS occurred in 56 and 48% of the lamotrigine 200 and 50 mg/day groups, respectively, compared with 29% for placebo (P<0.05). There was no evidence that lamotrigine destabilised mood or precipitated mania. Tolerability was good and there were no cases of serious rashes. Preliminary results from an ongoing study also indicate that lamotrigine is more effective than gabapentin in bipolar depression. In conclusion, lamotrigine is effective in alleviating bipolar depression, without causing mood destabilisation. Slow dosage escalation yields good tolerability. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:S113 / S117
页数:5
相关论文
共 18 条
[1]   New concepts in mood stabilization: Evidence for the effectiveness of valproate and lamotrigine [J].
Bowden, CL .
NEUROPSYCHOPHARMACOLOGY, 1998, 19 (03) :194-199
[2]   The efficacy of lamotrigine in rapid cycling and non-rapid cycling patients with bipolar disorder [J].
Bowden, CL ;
Calabrese, JR ;
McElroy, SL ;
Rhodes, LJ ;
Keck, PE ;
Cookson, J ;
Anderson, J ;
Bolden-Watson, C ;
Ascher, J ;
Monaghan, E ;
Zhou, J .
BIOLOGICAL PSYCHIATRY, 1999, 45 (08) :953-958
[3]  
CALABRESE J, 1999, IN PRESS AM J PSYCHI
[4]  
CALABRESE J, 1997, EUR NEUROPSYCHOPHARM, V7, pS177
[5]   A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression [J].
Calabrese, JR ;
Bowden, CL ;
Sachs, GS ;
Ascher, JA ;
Monaghan, E ;
Rudd, GD .
JOURNAL OF CLINICAL PSYCHIATRY, 1999, 60 (02) :79-+
[6]  
Calabrese JR, 1996, AM J PSYCHIAT, V153, P1236
[7]   Lamotrigine in rapid-cycling bipolar disorder [J].
Fatemi, SH ;
Rapport, DJ ;
Calabrese, JR ;
Thuras, P .
JOURNAL OF CLINICAL PSYCHIATRY, 1997, 58 (12) :523-527
[8]   Lamotrigine treatment of refractory bipolar disorder [J].
Fogelson, DL ;
Sternbach, H .
JOURNAL OF CLINICAL PSYCHIATRY, 1997, 58 (06) :271-273
[9]  
FRYE M, 1998, SYLL P SUMM AM PSYCH, P150
[10]   LAMOTRIGINE - AN ANTIEPILEPTIC AGENT FOR THE TREATMENT OF PARTIAL SEIZURES [J].
GILMAN, JT .
ANNALS OF PHARMACOTHERAPY, 1995, 29 (02) :144-151