Regulation of leukocyte trafficking by lipoxins

被引：25

作者：

Diamond, P ^{[1
]}

McGinty, A ^{[1
]}

Sugrue, D ^{[1
]}

Brady, HR ^{[1
]}

Godson, C ^{[1
]}

机构：

[1] Univ Coll Dublin, Mater Misericordiae Hosp, Ctr Vasc Inflammat & Vasc Res, Dept Med & Therapeut, Dublin 7, Ireland

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 1999年 / 37卷 / 03期

关键词：

lipoxins; leukotrienes; leukocyte trafficking; adhesion molecules;

D O I：

10.1515/CCLM.1999.051

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Lipoxins are lipoxygenase interaction products formed by transcellular metabolism during host defence and inflammation. In model systems, lipoxins modulate polymorphonuclear leukocytes (PMN) chemotaxis, adhesion molecule expression, inhibit PMN-endothelial cell adhesion, and attenuate cytokine release from epithelial cells. These observations raise the possibility that lipoxins are 'stop signals' for PMN-mediated tissue injury and promote the resolution of acute inflammation.

引用

收藏

页码：293 / 297

页数：5

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