Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

被引：268

作者：

Lu, Xiangfeng ^{[1
,2
]}

Wang, Laiyuan ^{[1
,2
,3
]}

Chen, Shufeng ^{[1
,2
]}

He, Lin ^{[4
]}

Yang, Xueli ^{[1
,2
]}

Shi, Yongyong ^{[4
]}

Cheng, Jing ^{[5
,6
]}

Zhang, Liang ^{[5
]}

Gu, C. Charles ^{[7
]}

Huang, Jianfeng ^{[1
,2
]}

Wu, Tangchun ^{[8
]}

Ma, Yitong ^{[9
]}

Li, Jianxin ^{[1
,2
]}

Cao, Jie ^{[1
,2
]}

Chen, Jichun ^{[1
,2
]}

Ge, Dongliang ^{[1
,2
]}

Fan, Zhongjie ^{[10
]}

Li, Ying ^{[1
,2
]}

Zhao, Liancheng ^{[1
,2
]}

Li, Hongfan ^{[3
]}

Zhou, Xiaoyang ^{[11
]}

Chen, Lanying ^{[1
,2
]}

Liu, Donghua ^{[1
,2
]}

Chen, Jingping ^{[1
,2
]}

Duan, Xiufang ^{[1
,2
]}

Hao, Yongchen ^{[1
,2
]}

Wang, Ligui ^{[8
]}

Lu, Fanghong ^{[12
]}

Liu, Zhendong ^{[12
]}

Yao, Cailiang ^{[13
]}

Shen, Chong ^{[13
]}

Pu, Xiaodong ^{[14
]}

Yu, Lin ^{[14
]}

Fang, Xianghua ^{[15
]}

Xu, Lihua ^{[16
]}

Mu, Jianjun ^{[17
]}

Wu, Xianping ^{[18
]}

Zheng, Runping ^{[19
]}

Wu, Naqiong ^{[2
,20
]}

Zhao, Qi ^{[1
,2
]}

Li, Yun ^{[21
]}

Liu, Xiaoli ^{[22
]}

Wang, Mengqin ^{[23
]}

Yu, Dahai ^{[1
,2
]}

Hu, Dongsheng ^{[24
,25
]}

Ji, Xu ^{[26
]}

Guo, Dongshuang ^{[27
]}

Sun, Dongling ^{[28
]}

Wang, Qianqian ^{[1
,2
]}

Yang, Ying ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, State Key Lab Cardiovasc Dis, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Beijing 100730, Peoples R China

[2] Peking Union Med Coll, Beijing 100021, Peoples R China

[3] Natl Human Genome Ctr, Beijing, Peoples R China

[4] Shanghai Jiao Tong Univ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai 200030, Peoples R China

[5] NERCBBT, Beijing, Peoples R China

[6] Tsinghua Univ, Med Syst Biol Res Ctr, Sch Med, Beijing 100084, Peoples R China

[7] Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA

[8] Huazhong Univ Sci & Technol, Key Lab Environm & Hlth, Sch Publ Hlth, Tongji Med Coll, Wuhan 430074, Peoples R China

[9] Xinjiang Med Univ, Dept Cardiol, Affiliated Hosp 1, Urumqi, Peoples R China

[10] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Cardiol, Beijing 100730, Peoples R China

[11] Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan 430072, Peoples R China

[12] Shandong Acad Med Sci, Inst Basic Med, Cardiocerebrovasc Control & Res Ctr, Jinan, Peoples R China

[13] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing, Jiangsu, Peoples R China

[14] Fujian Prov Peoples Hosp, Dept Cardiol, Fuzhou, Peoples R China

[15] Capital Med Univ, Xuanwu Hosp, Dept Epidemiol & Social Med, Beijing, Peoples R China

[16] Beihua Univ, Affiliated Hosp, Dept Cardiol, Jilin, Peoples R China

[17] Xi An Jiao Tong Univ, Affiliated Hosp 1, Coll Med, Dept Cardiol, Xian 710049, Peoples R China

[18] Sichuan Ctr Dis Control & Prevent, Ctr Chron & Noncommunicable Dis Control & Prevent, Chengdu, Peoples R China

[19] Peking Univ, Shougang Hosp, Cardiovasc Dis Prevent Ctr, Beijing 100871, Peoples R China

[20] Chinese Acad Med Sci, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Cardiol, Beijing 100730, Peoples R China

[21] Hebei United Univ, Sch Publ Hlth, Tangshan, Peoples R China

[22] Capital Med Univ, Anzhen Hosp, Dept Cardiol, Beijing, Peoples R China

[23] Beijing Jishuitan Hosp, Dept Emergency Med, Beijing, Peoples R China

[24] Zhengzhou Univ, Sch Publ Hlth, Zhengzhou, Peoples R China

[25] Shenzhen Univ, Sch Med, Shenzhen, Peoples R China

[26] Xinle Red Cross Hosp, Dept Internal Med, Xinle, Peoples R China

[27] Yuxian Renmin Hosp, Dept Internal Med, Yuxian, Peoples R China

[28] Chinese Peoples Liberat Army PLA Gen Hosp, Inst Geriatr, Beijing, Peoples R China

[29] Renqiu Heath Bur, Renqiu, Peoples R China

[30] Nantong Ctr Dis Control & Prevent, Nantong, Peoples R China

[31] Zhangqiu Heath Bur, Zhangqiu, Peoples R China

[32] Xinan Heath Bur, Xinan, Peoples R China

[33] Shijiazhuang Greatwall Hosp, Dept Internal Med, Shijiazhuang, Peoples R China

[34] Hanzhong Renmin Hosp, Dept Cardiol, Hanzhong, Peoples R China

[35] Univ Lubeck, Med Klin 2, Lubeck, Germany

[36] Univ Lubeck, Deutsch Zentrum Herz Kreislauf Forsch DZHK, Lubeck, Germany

[37] Univ Leicester, Dept Cardiovasc Sci, Glenfield Hosp, Leicester, Leics, England

[38] Glenfield Hosp, Biomed Res Unit Cardiovasc Dis, Leicester Natl Inst Hlth Res, Leicester, Leics, England

[39] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA

[40] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA

[41] Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA

[42] Univ Penn, Cardiovasc Inst, Philadelphia, PA 19104 USA

[43] Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100730, Peoples R China

[44] Chinese Acad Sci, Inst Biophys, Beijing 100080, Peoples R China

来源：

NATURE GENETICS | 2012年 / 44卷 / 08期

基金：

美国国家科学基金会;

关键词：

BLOOD-PRESSURE; MYOCARDIAL-INFARCTION; COMMON VARIANTS; EAST ASIANS; METAANALYSIS; POPULATION; SEQUENCE; ONSET;

D O I：

10.1038/ng.2337

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 x 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.

引用

页码：890 / +

页数：7

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