Synthesis of benzofuroquinolizine for α-2 adrenoceptor antagonist MK-912:: an O-analogue of the Pictet-Spengler reaction

被引：10

作者：

Albaneze-Walker, J ^{[1
]}

Rossen, K ^{[1
]}

Reamer, RA ^{[1
]}

Volante, RP ^{[1
]}

Reider, PJ ^{[1
]}

机构：

[1] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 27期

关键词：

D O I：

10.1016/S0040-4039(99)00840-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient synthesis of benzofuroquinolizine ketone 1 was accomplished in four steps from ethyl 3-benzofuranacetate. The O-analogue of the Pictet-Spengler cyclization was used to form the benzofuroquinolizine ring structure as a key step. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4917 / 4920

页数：4

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