Modeling retention of inhaled particles in rat lungs including toxic and overloading effects

被引：29

作者：

Gradon, L ^{[1
]}

Pratsinis, SE ^{[1
]}

Podgorski, A ^{[1
]}

Scott, SJ ^{[1
]}

Panda, S ^{[1
]}

机构：

[1] WARSAW UNIV TECHNOL,DEPT CHEM ENGN,WARSAW,POLAND

来源：

JOURNAL OF AEROSOL SCIENCE | 1996年 / 27卷 / 03期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0021-8502(95)00570-6

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

A theoretical model describing the retention of insoluble particles in rat lungs after prolonged exposure to an aerosol is presented. The retention kinetics of particle deposition have been determined based on the particle deposition flux and residence time of the aerosol in all generations of the respiratory system, accounting for both mucociliary and pulmonary clearance effects. The model predictions are in good agreement with inhalation data from the literature of diesel soot particles of mass median diameter 0.25 mu m, titanium dioxide particles of aerodynamic diameter 1.5 mu m, and quartz particles of aerodynamic diameter 2.5 mu m. The model indicates that particle retention in the lungs is strongly influenced by the particle toxicity and concentration in the inhaled air. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：487 / 503

页数：17

共 48 条

[1] MODEL OF PARTICLE ALVEOLAR MACROPHAGE RELATIONSHIPS DURING THE ALVEOLAR CLEARANCE OF A LOW LUNG BURDEN OF INSTILLED PARTICLES [J].