Synthesis and Antifungal Activity of Novel 2-(1H-Benzimidazol-2-yl)-5-substituted-1,3,4-oxadiazole Derivatives

被引：8

作者：

Ji, Zengchen ^{[1
]}

Liu, Feng ^{[1
]}

Zhang, Zeyuan ^{[2
]}

Li, Fubo ^{[1
]}

Jiang, Lin ^{[2
]}

机构：

[1] Shandong Agr Univ, Coll Plant Protect, Tai An 271018, Shandong, Peoples R China

[2] Shandong Agr Univ, Coll Chem & Mat Sci, Tai An 271018, Shandong, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 32卷 / 11期

关键词：

benzimidazole; 1,3,4-oxadiazole; synthesis; antifungal activity; FUNGICIDAL ACTIVITY;

D O I：

10.6023/cjoc201205016

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

Sixteen novel 2-(1H-benzimidazol-2-y1)-5-substituted phenyl-1,3,4-oxadiazoles and 2-(1H-benzimidazol-2-y1)-5-substituted phenylamino-1,3,4-oxadiazoles were synthesized from benzimidazole-2-carboxylic acid, hydrazine hydrate, substituted phenyl isothiocyanate and substituted benzoic acid by multi-step reactions. The target compounds were evaluated for their antifungal activities against Botrytis cinerea and Sclerotinia sclerotiorum, and the results indicated that three target compounds displayed excellent antifungal activities against Botrytis cinerea, with EC50 values of 2.55, 6.34 and 5.12 mu g/mL, respectively, even higher than that of carbendazim.

引用

收藏

页码：2129 / 2133

页数：5

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