Opsonophagocytosis of fluorescent polystyrene beads coupled to Neisseria meningitidis serogroup A, C, Y, or W135 polysaccharide correlates with serum bactericidal activity

被引：18

作者：

Martinez, J

Pilishvili, T

Barnard, S

Caba, J

Spear, W

Romero-Steiner, S

Carlone, GM

机构：

[1] CDCP, Resp Dis Immunol Sect, Div Bacterial & Mycot Dis, Natl Ctr Infect Dis, Atlanta, GA 30333 USA

[2] Univ Glasgow, Glasgow, Lanark, Scotland

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2002年 / 9卷 / 02期

关键词：

D O I：

10.1128/CDLI.9.2.485-488.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We developed a polysaccharide-specific flow cytometric opsonophagocytic assay (OPA) for the simultaneous measurement of functional antibody to Neisseria meningitidis serogroups A, C, Y, and W135. OPA titers significantly correlated with serum bactericidal assay titers for all serogroups tested (mean r = 0.96; P < 0.001). OPA could be used in meningococcal vaccine evaluation.

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页码：485 / 488

页数：4

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