Signaling networks of Rho GTPases in cell motility

被引：253

作者：

Hanna, Samer ^{[1
]}

El-Sibai, Mirvat ^{[1
]}

机构：

[1] Lebanese Amer Univ, Dept Nat Sci, Beirut 11022801, Lebanon

来源：

CELLULAR SIGNALLING | 2013年 / 25卷 / 10期

关键词：

Motility; Rho GTPases; Actin; Cancer; PI3K; GTP-BINDING PROTEIN; MTLN3; CARCINOMA-CELLS; ACTIN STRESS FIBERS; BREAST-CANCER CELLS; FOCAL ADHESIONS; PLECKSTRIN HOMOLOGY; CYCLE PROGRESSION; MIGRATING CELLS; ARP2/3; COMPLEX; BARBED ENDS;

D O I：

10.1016/j.cellsig.2013.04.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The last decades have witnessed an exponential increase in our knowledge of Rho GTPase signaling network which further highlighted the cross talk between these proteins and the complexity of their signaling pathways. In this review, we summarize the upstream and downstream players from Rho GTPases that are mainly involved in actin polymerization leading to cell motility and potentially playing a role in cancer cell metastasis. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.

引用

页码：1955 / 1961

页数：7

共 87 条

[1]

Ananthakrishnan R, 2007, INT J BIOL SCI, V3, P303

[2]

A tale of two Paks [J].

Arias-Romero, Luis E. ;

Chernoff, Jonathan .

BIOLOGY OF THE CELL, 2008, 100 (02) :97-108

[3]

Filopodia and adhesion in cancer cell motility [J].

Arjonen, Antti ;

Kaukonen, Riina ;

Ivaska, Johanna .

CELL ADHESION & MIGRATION, 2011, 5 (05) :421-430

[4]

Bailly M, 1998, MICROSC RES TECHNIQ, V43, P433, DOI 10.1002/(SICI)1097-0029(19981201)43:5<433::AID-JEMT9>3.0.CO

[5]

2-2

[6]

Relationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulation [J].

Bailly, M ;

Macaluso, F ;

Cammer, M ;

Chan, A ;

Segall, JE ;

Condeelis, JS .

JOURNAL OF CELL BIOLOGY, 1999, 145 (02) :331-345

[7]

ADF/Cofilin: a functional node in cell biology [J].

Bernstein, Barbara W. ;

Bamburg, James R. .

TRENDS IN CELL BIOLOGY, 2010, 20 (04) :187-195

[8]

Rho GTPases and their effector proteins [J].

Bishop, AL ;

Hall, A .

BIOCHEMICAL JOURNAL, 2000, 348 (02) :241-255

[9]

A Novel Spatiotemporal RhoC Activation Pathway Locally Regulates Cofilin Activity at Invadopodia [J].

Bravo-Cordero, Jose Javier ;

Oser, Matthew ;

Chen, Xiaoming ;

Eddy, Robert ;

Hodgson, Louis ;

Condeelis, John .

CURRENT BIOLOGY, 2011, 21 (08) :635-644

[10]

A nucleator arms race: cellular control of actin assembly [J].

Campellone, Kenneth G. ;

Welch, Matthew D. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2010, 11 (04) :237-251

← 1 2 3 4 5 6 7 8 9 →