The Hippo-YAP pathway: new connections between regulation of organ size and cancer

被引：392

作者：

Zhao, Bin ^{[2
,3
,4
]}

Lei, Qun-Ying ^{[1
,5
]}

Guan, Kun-Liang ^{[2
,3
]}

机构：

[1] Fudan Univ, Dept Biol Chem, Sch Med, Shanghai 200032, Peoples R China

[2] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA

[4] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA

[5] Fudan Univ, Mol & Cellular Biol Lab, Inst Biomed Sci, Shanghai 200032, Peoples R China

来源：

CURRENT OPINION IN CELL BIOLOGY | 2008年 / 20卷 / 06期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

D O I：

10.1016/j.ceb.2008.10.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The control of organ size is a basic biological question. In the past several years, the Hippo signaling pathway has been delineated and shown to be crucial in control of organ size in both Drosophila and mammals. Acting downstream of the Hippo pathway is the Yki/YAP/TAZ transcription co-activators. In mammalian cells, the Hippo pathway kinase cascade inhibits YAP and its paralog TAZ by phosphorylation and promotion of their cytoplasmic localization. The TEAD family transcription factors have recently been identified as evolutionarily conserved key mediators of YAP biological functions. yap is a candidate oncogene, and several other components of the Hippo pathway are tumor suppressors. Dysregulation of the Hippo pathway contributes to the loss of contact inhibition observed in cancer cells. Therefore, the Hippo-YAP pathway connects the regulation of organ size and tumorigenesis.

引用

页码：638 / 646

页数：9

共 77 条

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