APOE genotype influences acquisition and recall following traumatic brain injury

被引：161

作者：

Crawford, FC

Vanderploeg, RD

Freeman, MJ

Singh, S

Waisman, M

Michaels, L

Abdullah, L

Warden, D

Lipsky, R

Salazar, A

Mullan, MJ

机构：

[1] Univ S Florida, Roskamp Inst, Tampa, FL 33613 USA

[2] James A Haley Vet Hosp, Tampa, FL 33612 USA

[3] Def & Vet Head Injury Program, Tampa, FL USA

[4] Walter Reed Army Med Ctr, Def & Vet Head Injury Program, Washington, DC 20307 USA

[5] NIAAA, Neurogenet Lab, NIH, Bethesda, MD USA

[6] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA

来源：

NEUROLOGY | 2002年 / 58卷 / 07期

关键词：

D O I：

10.1212/WNL.58.7.1115

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

APOE has been demonstrated to influence traumatic brain injury (TBI) outcome. The relationship between APOE genotype and memory following TBI was examined in 110 participants in the Defense and Veterans' Head Injury Program. Memory performance was worse in those who had an APOE epsilon4 allele (n = 30) than those who did not (n = 80), whereas genotype groups did not differ on demographic or injury variables or on measures of executive functioning. These data support a specific role for the APOE protein in memory outcome following TBI, and suggest an APOE isoform-specific effect on neuronal repair processes.

引用

页码：1115 / 1118

页数：4

共 11 条

[1]

Fagan AM, 2000, MICROSC RES TECHNIQ, V50, P297, DOI 10.1002/1097-0029(20000815)50:4<297::AID-JEMT9>3.0.CO

[2]

2-C

[3] Apolipoprotein E-ε4 genotype predicts a poor outcome in survivors of traumatic brain injury [J].