Effect of Acanthopanax senticosus stem on mast cell-dependent anaphylaxis

被引：67

作者：

Yi, JM

Hong, SH

Kim, JH

Kim, HK

Song, HJ

Kim, HM ^{[1
]}

机构：

[1] Wonkwang Univ, Korea Inst Oriental Pharm, Coll Pharm, Dept Oriental Pharm, Iksan 570749, Chonbuk, South Korea

[2] Wonkwang Univ, Coll Oriental Med, Iksan 570749, Chonbuk, South Korea

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2002年 / 79卷 / 03期

关键词：

anaphylaxis; Acanthopanax senticosus; histamine; mast cells; tumor necrosis factor-alpha;

D O I：

10.1016/S0378-8741(01)00403-2

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

We studied the effect of Acanthopanax senticosus stem (ACPS) on mast cell-dependent anaphylaxis. ACPS inhibited compound 48/80-induced systemic anaphylaxis at a dose of 1.0 g/kg by 50%. ACPS also inhibited passive cutaneous anaphylaxis reaction and histamine release from mast cells in a dose-dependent manner, respectively. Moreover, ACPS had an inhibitory effect on anti-dinitrophenyl IgE-induced turner necrosis factor-alpha (TNF-alpha) production from mast cells. These results indicate that ACPS inhibits mast cell-mediated anaphylaxis in vivo and in vitro murine model. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：347 / 352

页数：6

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