Cellular memory of transcriptional states by Polycomb-group proteins

被引：68

作者：

Jacobs, JJL ^{[1
]}

van Lohuizen, M ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1999年 / 10卷 / 02期

关键词：

cellular memory; chromatin; homeotic transformations; Polycomb-group; proliferation defects;

D O I：

10.1006/scdb.1999.0304

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Polycomb-group constitutes an important, widely conserved group of transcriptional repressors best known for their function in stably maintaining the inactive expression patterns of hey developmental regulators, including homeotic genes. Together with the counteracting trithorax-group proteins, they establish a form of cellular memory by faithfully maintaining transcription states determined early in embryogenesis. Besides being crucial for the correct execution of developmental programs, Polycomb-group mediated silencing also appears to be involved in controlling cell proliferation. Here we discuss several aspects of Pc-G function: target gene specificity and recognition as well as propagation of inactive chromatin states to subsequent cell generations.

引用

页码：227 / 235

页数：9

共 90 条

[1] PHENOTYPIC CONSEQUENCES AND GENETIC INTERACTIONS OF A NULL MUTATION IN THE DROSOPHILA-POSTERIOR SEX COMBS GENE
ADLER, PN
MARTIN, EC
CHARLTON, J
JONES, K
[J]. DEVELOPMENTAL GENETICS, 1991, 12 (05): : 349 - 361
[2] Akasaka T, 1996, DEVELOPMENT, V122, P1513
[3] The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors
Akasaka, T
Tsuji, K
Kawahira, H
Kanno, M
Harigaya, K
Hu, LN
Ebihara, Y
Nakahata, T
Tetsu, O
Taniguchi, M
Koseki, H
[J]. IMMUNITY, 1997, 7 (01) : 135 - 146
[4] TRANSFORMATION OF AXIAL SKELETON DUE TO OVEREXPRESSION OF BMI-1 IN TRANSGENIC MICE
ALKEMA, MJ
VANDERLUGT, NMT
BOBELDIJK, RC
BERNS, A
VANLOHUIZEN, M
[J]. NATURE, 1995, 374 (6524) : 724 - 727
[5] Perturbation of B and T cell development and predisposition to lymphomagenesis in E mu Bmi1 transgenic mice require the Bmi1 RING finger
Alkema, MJ
Jacobs, H
vanLohuizen, M
Berns, A
[J]. ONCOGENE, 1997, 15 (08) : 899 - 910
[6] Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian Polycomb complex
Alkema, MJ
Bronk, M
Verhoeven, E
Otte, A
vantVeer, LT
Berns, A
vanLohuizen, M
[J]. GENES & DEVELOPMENT, 1997, 11 (02) : 226 - 240
[7] Bel S, 1998, DEVELOPMENT, V125, P3543
[8] Bornemann D, 1996, DEVELOPMENT, V122, P1621
[9] MATERNAL EXPRESSION OF GENES THAT REGULATE THE BITHORAX COMPLEX OF DROSOPHILA-MELANOGASTER
BREEN, TR
DUNCAN, IM
[J]. DEVELOPMENTAL BIOLOGY, 1986, 118 (02) : 442 - 456
[10] The Drosophila polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1
Brown, JL
Mucci, D
Whiteley, M
Dirksen, ML
Kassis, JA
[J]. MOLECULAR CELL, 1998, 1 (07) : 1057 - 1064

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