Use of Imaging in Restorative Stroke Trials

被引:7
作者
Cramer, Steven C. [1 ,2 ]
机构
[1] Univ Calif Irvine, Dept Neurol, Irvine, CA 92717 USA
[2] Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92717 USA
关键词
stroke; plasticity; recovery; brain mapping; FUNCTIONAL RECOVERY; MOTOR CORTEX; THERAPY; GAINS;
D O I
10.1161/STROKEAHA.108.530576
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Restorative therapies aim to improve behavioral outcome after stroke by promoting repair and restoration. Measures of CNS injury and function might be useful to evaluate such therapies in a clinical trial, for example, by optimizing patient selection or treatment dose. These issues are considered in this review, with specific examples provided. (Stroke. 2009;40[suppl 1]:S28-S29.)
引用
收藏
页码:S28 / S29
页数:2
相关论文
共 11 条
[1]   The interventional management of stroke (IMS) II study [J].
Broderick, Joseph P. .
STROKE, 2007, 38 (07) :2127-2135
[2]   Analysis of fMRI and finger tracking training in subjects with chronic stroke [J].
Carey, JR ;
Kimberley, TJ ;
Lewis, SM ;
Auerbach, EJ ;
Dorsey, L ;
Rundquist, P ;
Ugurbil, K .
BRAIN, 2002, 125 :773-788
[3]   Predicting functional gains in a stroke trial [J].
Cramer, Steven C. ;
Parrish, Todd B. ;
Levy, Robert M. ;
Stebbins, Glenn T. ;
Ruland, Sean D. ;
Lowry, David W. ;
Trouard, Theodore P. ;
Squire, Scott W. ;
Weinand, Martin E. ;
Savage, Cary R. ;
Wilkinson, Steven B. ;
Juranek, Jenifer ;
Leu, Szu-Yun ;
Himes, David M. .
STROKE, 2007, 38 (07) :2108-2114
[4]   Motor cortex activation during treatment may predict therapeutic gains in paretic hand function after stroke [J].
Dong, Yun ;
Dobkin, Bruce H. ;
Cen, Steven Y. ;
Wu, Allan D. ;
Winstein, Carolee J. .
STROKE, 2006, 37 (06) :1552-1555
[5]   Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction [J].
Kawamata, T ;
Dietrich, WD ;
Schallert, T ;
Gotts, JE ;
Cocke, RR ;
Benowitz, LI ;
Finklestein, SP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (15) :8179-8184
[6]   Growth factor-stimulated generation of new cortical tissue and functional recovery after stroke damage to the motor cortex of rats [J].
Kolb, Bryan ;
Morshead, Cindi ;
Gonzalez, Claudia ;
Kim, Mina ;
Gregg, Christopher ;
Shingo, Tetsuro ;
Weiss, Samuel .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2007, 27 (05) :983-997
[7]   Immediate and long-term changes in corticomotor output in response to rehabilitation: Correlation with functional improvements in chronic stroke [J].
Koski, L ;
Mernar, TJ ;
Dobkin, BH .
NEUROREHABILITATION AND NEURAL REPAIR, 2004, 18 (04) :230-249
[8]   Effect of levodopa in combination with physiotherapy on functional motor recovery after stroke:: a prospective, randomised, double-blind study [J].
Scheidtmann, K ;
Fries, W ;
Müller, F ;
Koenig, E .
LANCET, 2001, 358 (9284) :787-790
[9]   Functional potential in chronic stroke patients depends on corticospinal tract integrity [J].
Stinear, Cathy M. ;
Barber, P. Alan ;
Smale, Peter R. ;
Coxon, James P. ;
Fleming, Melanie K. ;
Byblow, Winston D. .
BRAIN, 2007, 130 :170-180
[10]   Robot-based hand motor therapy after stroke [J].
Takahashi, Craig D. ;
Der-Yeghiaian, Lucy ;
Le, Vu ;
Motiwala, Rehan R. ;
Cramer, Steven C. .
BRAIN, 2008, 131 :425-437