Up-regulation of miR-182 expression in colorectal cancer tissues and its prognostic value

被引：93

作者：

Liu, Hui ^{[1
]}

Du, Lutao ^{[1
]}

Wen, Zhihua ^{[2
]}

Yang, Yongmei ^{[1
]}

Li, Juan ^{[1
]}

Wang, Lili ^{[1
]}

Zhang, Xin ^{[1
]}

Liu, Yimin ^{[1
]}

Dong, Zhaogang ^{[1
]}

Li, Wei ^{[1
]}

Zheng, Guixi ^{[1
]}

Wang, Chuanxin ^{[1
]}

机构：

[1] Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Qilu Hosp, Inst Basic Med Sci, Jinan 250012, Shandong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | 2013年 / 28卷 / 05期

关键词：

Colorectal cancer; MiR-182; Quantitative real-time PCR; Prognosis; COLON-CANCER; MICRORNA; METASTASIS; PROLIFERATION; PROGRESSION; DISCOVERY;

D O I：

10.1007/s00384-013-1674-0

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Accumulating evidences indicate that dysregulated microRNAs (miRNA) are involved in cancer tumorigenesis and progression. In the present study, we evaluated the expression of miR-182 in colorectal cancer and adjacent noncancerous tissues and explored its associations with clinicopathological characteristics and prognosis. Quantitative real-time PCR was used to analyze the expression of miR-182 in 148 pairs of colorectal cancer and adjacent noncancerous tissues. The relationship between miR-182 expression and clinicopathological characteristics in colorectal cancer tissues was estimated using Mann-Whitney U test or Kruskal-Wallis test, as appropriate. We calculated the survival curves and prognostic values of each variable by the Kaplan-Meier method and Cox proportional hazards regression analysis, respectively. The expression of miR-182 was found up-regulated in colorectal cancer tissues compared with adjacent noncancerous tissues (p < 0.001), and its up-regulation was significantly correlated with large tumor size (p = 0.016), positive regional lymph node metastasis (p = 0.008), and advanced tumor-node-metastasis stage (p = 0.020). Furthermore, Kaplan-Meier analysis demonstrated that high miR-182 expression predicted poor survival (p = 0.001), and Cox proportional hazards risk analysis indicated that miR-182 was an independent prognostic factor for colorectal cancer. MiR-182 was up-regulated in colorectal cancer tissues and correlated with adverse clinical characteristics and poor prognosis, indicating that miR-182 might be involved in colorectal cancer progression and could be used as a potential prognostic biomarker and therapeutic target in the management of colorectal cancer.

引用

页码：697 / 703

页数：7

共 28 条

[1]

bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila [J].