Effect of homocysteine on the production of nitric oxide in endothelial cells

被引:31
作者
Chow, K
Cheung, F
Lao, TTH
O, K
机构
[1] Univ Hong Kong, Dept Pharmacol, Fac Med, Hong Kong, Peoples R China
[2] Univ Hong Kong, Dept Obstet & Gynecol, Fac Med, Hong Kong, Peoples R China
关键词
endothelial cells; homocysteine; nitric oxide; nitric oxide synthase;
D O I
10.1046/j.1440-1681.1999.03133.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. Homocysteine decreased the release of nitric oxide in cultured human umbilical vein endothelial cells. 2. Homocysteine did not affect constitutive and inducible nitric oxide synthase activity.
引用
收藏
页码:817 / 818
页数:2
相关论文
共 20 条
  • [1] PLASMA HOMOCYSTEINE BEFORE AND AFTER METHIONINE LOADING WITH REGARD TO AGE, GENDER, AND MENOPAUSAL STATUS
    ANDERSSON, A
    BRATTSTROM, L
    ISRAELSSON, B
    ISAKSSON, A
    HAMFELT, A
    HULTBERG, B
    [J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1992, 22 (02) : 79 - 87
  • [2] A QUANTITATIVE ASSESSMENT OF PLASMA HOMOCYSTEINE AS A RISK FACTOR FOR VASCULAR-DISEASE - PROBABLE BENEFITS OF INCREASING FOLIC-ACID INTAKES
    BOUSHEY, CJ
    BERESFORD, SAA
    OMENN, GS
    MOTULSKY, AG
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 274 (13): : 1049 - 1057
  • [3] HYPERHOMOCYSTEINEMIA - AN INDEPENDENT RISK FACTOR FOR VASCULAR-DISEASE
    CLARKE, R
    DALY, L
    ROBINSON, K
    NAUGHTEN, E
    CAHALANE, S
    FOWLER, B
    GRAHAM, I
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (17) : 1149 - 1155
  • [4] ENDOTHELIUM-DERIVED NITRIC-OXIDE PLAYS A LARGER ROLE IN PULMONARY VEINS THAN IN ARTERIES OF NEWBORN LAMBS
    GAO, YS
    ZHOU, HY
    RAJ, JU
    [J]. CIRCULATION RESEARCH, 1995, 76 (04) : 559 - 565
  • [5] TOTAL HOMOCYST(E)INE IN PLASMA AND AMNIOTIC-FLUID OF PREGNANT-WOMEN
    KANG, SS
    WONG, PWK
    ZHOU, J
    COOK, HY
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1986, 35 (10): : 889 - 891
  • [6] INDUCTION OF NITRIC-OXIDE SYNTHASE GENE BY INTERLEUKIN IN VASCULAR SMOOTH-MUSCLE CELLS
    KANNO, K
    HIRATA, Y
    IMAI, T
    MARUMO, F
    [J]. HYPERTENSION, 1993, 22 (01) : 34 - 39
  • [7] THE EMERGING MULTIFACETED ROLES OF NITRIC-OXIDE
    KUO, PC
    SCHROEDER, RA
    [J]. ANNALS OF SURGERY, 1995, 221 (03) : 220 - 235
  • [8] LENTZ SR, 1996, J CLIN INVEST, V98, P5
  • [9] The oxidant stress of hyperhomocyst(e)inemia
    Loscalzo, J
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (01) : 5 - 7
  • [10] NITRIC-OXIDE - A PHYSIOLOGICAL MESSENGER
    LOWENSTEIN, CJ
    DINERMAN, JL
    SNYDER, SH
    [J]. ANNALS OF INTERNAL MEDICINE, 1994, 120 (03) : 227 - 237