Serological pattern 'anti-hepatitis B core alone' in HIV or hepatitis C virus-infected patients is not fully explained by hepatitis B surface antigen mutants

被引：39

作者：

Wagner, AA

Denis, F

Weinbreck, P

Loustaud, V

Autofage, F

Rogez, S

Alain, S

机构：

[1] CHU Dupuytren, Teacher Hosp, Dept Bacteriol Virol & Hyg, F-87042 Limoges, France

[2] CHU Dupuytren, Teacher Hosp, Dept Infect Dis, F-87042 Limoges, France

[3] CHU Dupuytren, Teacher Hosp, Dept Internal Med, F-87042 Limoges, France

来源：

AIDS | 2004年 / 18卷 / 03期

关键词：

D O I：

10.1097/00002030-200402200-00028

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Serological pattern 'anti-hepatitis B core alone' in HIV or hepatitis C virus-infected patients is not fully explained by hepatitis B surface antigen mutants We determined the frequency of hepatitis B virus (HBV) occult infection and studied S gene mutations in HIV or hepatitis C virus-co-infected patients with persistent pattern 'anti-hepatitis B core alone'. HBV DNA was particularly frequent in HIV-positive patients. Sequencing of the S gene showed that only two HIV-infected patients harboured mutants in the major hydrophilic loop; the absence of hepatitis B surface antigen detection could not be explained by diagnostic escape mutants.

引用

页码：569 / 571

页数：3

共 6 条

[1] Characterization of a novel hepatitis B virus mutant: demonstration of mutation-induced hepatitis B virus surface antigen group specific 'a' determinant conformation change and its application in diagnostic assays [J].