Glucose stimulates chondrocyte differentiation of vascular smooth muscle cells and calcification: A possible role for IL-1β

被引：47

作者：

Bessueille, Laurence ^{[1
]}

Fakhry, Maya ^{[1
,2
]}

Hamade, Eva ^{[2
]}

Badran, Bassam ^{[2
]}

Magne, David ^{[1
]}

机构：

[1] Univ Lyon 1, Inst Mol & Supramol Chem & Biochem ICBMS, CNRS, UMR 5246, F-69622 Villeurbanne, France

[2] Lebanese Univ, Fac Sci, Genom & Hlth Lab, Beirut 999095, Lebanon

来源：

FEBS LETTERS | 2015年 / 589卷 / 19期

关键词：

Glucose; Diabetes mellitus; Vascular calcification; Vascular smooth muscle cells; Chondrocyte; IL-1; beta; MEDIAL ARTERY CALCIFICATION; ALKALINE-PHOSPHATASE; TNF-ALPHA; DIABETES-MELLITUS; CARTILAGINOUS METAPLASIA; OXIDATIVE STRESS; RISK-FACTORS; IN-VITRO; MINERALIZATION; INFLAMMASOME;

D O I：

10.1016/j.febslet.2015.07.045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Vascular calcification is a hallmark of type 2 diabetes. Glucose stimulates calcification in culture of vascular smooth muscle cells (VSMCs) but the underlying mechanisms remain obscure. We observed that high glucose levels stimulated mouse and human VSMC trans-differentiation into chondrocytes, with increased levels of Sox9, type II collagen, glycosaminoglycan and Runx2 expression, and increased alkaline phosphatase activity and mineralization. These effects were associated with increased expression of IL-1 beta, which stimulated alkaline phosphatase and calcification, suggesting that glucose induces chondrocyte differentiation of VSMCs, possibly through IL-1 beta activation. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2797 / 2804

页数：8

共 42 条

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Increase in GLUT1 in Smooth Muscle Alters Vascular Contractility and Increases Inflammation in Response to Vascular Injury [J].